Table 3

Association of Fetuin-A With Categorical Definitions of Subclinical CVD: The Rancho Bernardo Study

Fetuin-A Quartiles, Fetuin-A Range (g/l)Fetuin-A Continuous per SD (0.11 g/l) Greater
I ≤0.45II 0.45–0.51III 0.52–0.58IV ≥0.59
CAC severity (0, 1–100, 101–300, >300)
 n with CAC >0/total (%)69/8676/9766/9575/104286/382
 Age- and sex-adjusted1.00 (Ref)0.74 (0.43 to 1.27), 0.270.72 (0.42 to 1.25), 0.240.58 (0.34 to 0.99), 0.040.81 (0.67 to 0.98), 0.03
 Lifestyle-adjusted*1.00 (Ref)0.71 (0.41 to 1.24), 0.230.71 (0.41 to 1.23), 0.220.56 (0.33 to 0.98), 0.040.81 (0.66 to 0.98), 0.03
 Fully adjusted1.00 (Ref)0.65 (0.37 to 1.14), 0.130.61 (0.35 to 1.08), 0.090.45 (0.25 to 0.79), 0.0060.72 (0.59 to 0.89), 0.002
PAD (ABI <0.90)
 n with PAD/total (%)40/28036/27025/25028/245129/1,045
 Age- and sex-adjusted1.00 (Ref)0.99 (0.61 to 1.62), 0.980.73 (0.43 to 1.23), 0.240.88 (0.52 to 1.48), 0.620.93 (0.76 to 1.12), 0.43
 Lifestyle-adjusted*1.00 (Ref)1.02 (0.62 to 1.67), 0.940.72 (0.42 to 1.24), 0.240.87 (0.51 to 1.48), 0.600.92 (0.75 to 1.12), 0.40
 Fully adjusted1.00 (Ref)1.05 (0.63 to 1.73), 0.860.73 (0.42 to 1.26), 0.260.78 (0.45 to 1.37), 0.390.88 (0.71 to 1.08), 0.22
Common cIMT (>75th percentile vs. lower)
 n with high common cIMT/total (%)36/13129/15032/14852/168149/597
 Age- and sex-adjusted1.00 (Ref)0.73 (0.40 to 1.32), 0.300.77 (0.43 to 1.38), 0.381.79 (1.03 to 3.11), 0.041.27 (1.03 to 1.57), 0.02
 Lifestyle-adjusted*1.00 (Ref)0.72 (0.39 to 1.31), 0.280.76 (0.42 to 1.37), 0.351.76 (1.00 to 3.10), 0.051.27 (1.03 to 1.58), 0.03
 Fully adjusted1.00 (Ref)0.65 (0.35 to 1.20), 0.170.65 (0.35 to 1.20), 0.171.50 (0.84 to 2.69), 0.171.20 (0.96 to 1.50), 0.11
Internal cIMT (>75th percentile vs. lower)
 n with high internal cIMT/total (%)27/12533/14938/14347/166145/583
 Age- and sex-adjusted1.00 (Ref)1.06 (0.60 to 1.90), 0.831.32 (0.75 to 2.34), 0.341.66 (0.95 to 2.88), 0.071.19 (0.98 to 1.46), 0.08
 Lifestyle-adjusted*1.00 (Ref)1.09 (0.60 to 1.95), 0.781.34 (0.75 to 2.39), 0.321.66 (0.94 to 2.92), 0.081.20 (0.97 to 1.47), 0.09
 Fully adjusted1.00 (Ref)1.05 (0.57 to 1.93), 0.871.26 (0.69 to 2.30), 0.451.35 (0.74 to 2.47), 0.321.10 (0.88 to 1.36), 0.40

Values are odds ratio (95% confidence interval), p value.

PAD = peripheral arterial disease; other abbreviations as in Table 2.

  • * Adjusted for age, sex, current smoking, alcohol use, regular physical exercise, and oral estrogen use.

  • Adjusted for lifestyle model (*) plus diabetes, body mass index, total cholesterol, triglycerides, and estimated glomerular filtration rate.