Table 1

Potential Advantages and Disadvantages of Targeting Chemokines

AdvantagesDisadvantages
Precise and differentiated actions on leukocyte subsets and stem cells
Precise and differentiated actions on angiogenesis, collagen synthesis, and cardiac remodelingConcomitant actions are poorly studied
Specific and selective agonists and antagonists availablePrice
Local or systemic applicationsInterference with other organs by systemic applications (partly disadvantageous)
Very short action: side effects rapidly reversibleSometimes repetitive application is needed
Easy combination with other carrying systems (liposomes, microbubbles, nanoparticles)