Table 3

HR (95% CI) for the Relation of Blood Pressure in Early and Mid-Adulthood With CHD and Stroke Mortality (N = 18,881)—HAHS

nCHDStroke
DeathsAge-AdjustedAge- and University Covariate-Adjusted*Age-, University Covariate-, and Hypertension-Adjusted*DeathsAge-AdjustedAge- and University Covariate-Adjusted*Age-, University Covariate-, and Hypertension-Adjusted*
University entry (18.4 yrs)
 Per SD (13.1 mm Hg) increase in systolic blood pressure18,8811,9171.15 (1.10–1.20)1.14 (1.09–1.20)1.10 (1.05–1.16)5801.01 (0.93–1.09)1.00 (0.91–1.10)0.96 (0.88–1.05)
 Categories of systolic blood pressure, mm Hg
  <1051,7621480.94 (0.78–1.14)0.93 (0.75–1.16)0.93 (0.75–1.15)560.96 (0.70–1.31)0.95 (0.67–1.34)0.94 (0.67–1.34)
  105–1144,4363701.00 (ref)1.00 (ref)1.00 (ref)1341.00 (ref)1.00 (ref)1.00 (ref)
  115–1246,4916721.22 (1.08–1.39)1.17 (1.01–1.34)1.14 (0.99–1.31)1940.96 (0.77–1.19)0.93 (0.73–1.18)0.90 (0.71–1.15)
  125–1343,7963901.20 (1.04–1.38)1.16 (0.99–1.36)1.12 (0.96–1.32)1110.92 (0.71–1.18)0.82 (0.62–1.09)0.79 (0.59–1.04)
  135–1441,7072351.61 (1.37–1.90)1.54 (1.29–1.85)1.43 (1.19–1.71)591.08 (0.80–1.47)0.98 (0.70–1.38)0.90 (0.64–1.27)
  145–154470691.68 (1.30–2.18)1.67 (1.27–2.21)1.48 (1.12–1.95)191.23 (0.76–1.99)1.27 (0.77–2.10)1.11 (0.67–1.83)
  ≥155219331.72 (1.20–2.46)1.68 (1.13–2.50)1.36 (0.91–2.03)70.99 (0.45–2.05)1.13 (0.53–2.44)0.88 (0.41–1.91)
 p Value for trend18,8811,917<0.001<0.001<0.0015800.6300.8980.510
 Normal6,7485421.00 (ref)1.00 (ref)1.00 (ref)1801.00 (ref)1.00 (ref)1.00 (ref)
 Pre-hypertensive9,5779801.20 (1.08–1.33)1.21 (1.07–1.36)1.17 (1.03–1.32)2780.98 (0.81–1.18)0.99 (0.80–1.22)0.95 (0.76–1.17)
 Stage 1 hypertension2,1763151.43 (1.25–1.65)1.46 (1.25–1.70)1.33 (1.14–1.56)1041.27 (1.00–1.62)1.28 (0.98–1.67)1.16 (0.88–1.52)
 Stage 2 hypertension380801.93 (1.53–2.45)1.89 (1.46–2.45)1.63 (1.26–2.12)181.12 (0.69–1.83)1.28 (0.78–2.09)1.09 (0.66–1.79)
 p Value for trend18,8811,917<0.001<0.001<0.0015800.1220.0820.372
Middle-age (44.4 yrs)
 Nonhypertensive17,0071,5501.00 (ref)4591.00 (ref)
 Hypertensive1,8743672.06 (1.76–2.27)1212.18 (1.65–2.58)

Values are n or hazard ratio (95% confidence interval). Model 1: adjusted by age at college entry; Model 2: adjusted by age, BMI, cigarette smoking status. and physical activity at college entry; Model 3: adjusted by age, BMI, cigarette smoking status, and physical activity at college entry and hypertension in 1962/1966.

CHD = coronary heart disease; other abbreviations as in Table 1.

  • * n = 15,488 due to missing BMI, physical activity, and smoking status data.

  • Current Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure criteria categories: normotensive (<120/<80 mm Hg), pre-hypertension (120–139/80–89 mm Hg), stage 1 hypertension (140–159/90–99 mm Hg), and stage 2 hypertension (≥160/≥100 mm Hg).