Table 1

Functional Parameters of Wild-Type and Cxcr4+/− Hearts

Langendorff Perfusion
ParameterBefore MI4 Weeks After MI
Wild Type (n = 3–4)Cxcr4+/− (n = 3–5)Wild Type (n = 4–5)Cxcr4+/− (n = 5–6)
LVDP, mm Hg86.7 ± 8.878.3 ± 17.040.0 ± 10.150.0 ± 11.5
 Increase after dobutamine (Δ)40.3 ± 4.046.2 ± 5.213.8 ± 4.310.3 ± 2.6
dPdt max, mm Hg/s3,189 ± 993,058 ± 3631,540 ± 971,590 ± 94
 Increase after dobutamine (Δ)2,410 ± 6291,941 ± 187770 ± 91704 ± 74
dPdt min, mm Hg/s−2,695 ± 244−2,011 ± 411−1,267 ± 111−1,280 ± 79
 Increase after dobutamine (Δ)−1,756 ± 544−1,407 ± 314545 ± 28484 ± 68
Coronary flow, ml3.9 ± 0.22.0 ± 0.3*3.2 ± 0.31.2 ± 0.3*
 Increase after brief ischemia (Δ)3.4 ± 0.22.8 ± 0.11.8 ± 0.40.2 ± 0.1*

Values are mean ± SD.

dPdt = derivative of pressure increase (maximum) and decay (minimum); LVDP = left ventricular developed pressure; MI = myocardial infarction.

  • * p < 0.05 versus wild type.