Table 4

Event Rates, Adjusted HRs Across Ts of Heart Rate and Adjusted HRs for Each 10-Beats/Min Increase in Baseline Heart Rate for All-Cause Mortality and for CV Death or WHFH

All-Cause MortalityCV Death or WHFH
Event Rates (95% CI)/100 Patient-YrsHR (95% CI)HR (95% CI)/10-Beats/Min IncreaseEvent Rates (95% CI)/100 Patient-YrsHR (95% CI)HR (95% CI)/10-Beats/Min Increase
Overall
 T17.2 (6.6–7.8)1.0010.3 (9.5–11.1)1.00
 T28.3 (7.7–9.0)1.07 (0.95–1.20)12.8 (12.0–13.7)1.11 (1.01–1.23)
 T310.2 (9.4–11.0)1.27 (1.13–1.43)15.3 (14.3–16.4)1.23 (1.11–1.36)
 All patients1.06 (1.02–1.10)1.07 (1.04–1.10)
Reduced LVEF
 T18.9 (8.0–9.8)1.0012.5 (11.5–13.7)1.00
 T210.5 (9.6–11.5)1.10 (0.96–1.27)15.8 (14.6–17.1)1.15 (1.01–1.30)
 T312.2 (11.2–13.3)1.26 (1.09–1.45)18.4 (17.0–19.8)1.25 (1.11–1.42)
 All patients1.06 (1.02–1.10)1.07 (1.03–1.10)
Preserved LVEF
 T15.0 (4.3–5.8)1.007.4 (6.5–8.4)1.00
 T25.2 (4.4–6.1)1.05 (0.84–1.32)8.9 (7.8–10.0)1.14 (0.94–1.37)
 T36.3 (5.4–7.3)1.25 (0.99–1.58)9.8 (8.6–11.1)1.14 (0.93–1.38)
 All patients1.05 (0.98–1.12)1.06 (1.00–1.12)
No AF
 T16.7 (6.1–7.4)1.009.4 (8.7–10.2)1.00
 T27.7 (7.0–8.5)1.08 (0.94–1.23)12.0 (11.1–13.0)1.14 (1.02–1.28)
 T39.5 (8.8–10.4)1.26 (1.10–1.43)15.0 (14.0–16.1)1.28 (1.14–1.44)
 All patients1.08 (1.04–1.12)1.10 (1.06–1.13)
AF
 T111.6 (9.8–13.6)1.0018.3 (15.9–21.1)1.00
 T213.0 (10.9–15.5)1.15 (0.90–1.48)17.5 (14.9–20.6)0.97 (0.78–1.21)
 T310.3 (8.4–12.5)0.97 (0.75–1.26)14.3 (12.0–17.1)0.85 (0.67–1.07)
 All patients0.97 (0.90–1.05)0.95 (0.89–1.02)

CI = confidence interval; HR = hazard ratio; WHFH = hospital stay for worsening heart failure; other abbreviations as in Table 1.

  • Model is adjusted for age, LVEF, diabetes, body mass index, previous HF hospital stay, sex, NYHA functional class, radiologic cardiomegaly, diastolic blood pressure, randomized treatment, and beta-blocker use at baseline.