Table 3

Outcomes Associated With Aortic and/or Paravalvular Regurgitation

First Author, Year (Ref. #)nVariableOutcomeUnivariate AnalysisMultivariate Analysis
Abdel-Wahab, 2011 (3)690AR ≥2In-hospital mortalityOR = 2.50 (95% CI 1.37–4.55)OR = 2.43 (95% CI 1.22–4.85)
Gotzmann, 2011 (4)122AR ≥2
  • 6-month mortality

  • No clinical improvement

  • OR = 4.26 (95% CI 1.59–11.45)

  • OR = 10.1 (95% CI 3.20–31.94)

Takagi, 2011 (15)41AR ≥26-month mortality12.2% vs. 25.0% (p = 0.25)
Hayashida, 2012 (89)260AR ≥2Median 217 days (IQR: 54–401)HR = 1.97 (95% CI 1.19–3.28)
Leber, 2011 (90)69AR >21-year mortality9% vs. 37.5% (95% CI p = 0.07)
Moat, 2011 (5)870AR ≥21-year mortalityHR = 1.49 (95% CI 1.00–2.21)HR = 1.66 (95% CI 1.10–2.51)
Sinning, 2012 (91)152PVL ≥21-year mortalityHR = 4.0 (95% CI 2.1–7.5)HR = 4.9 (95% CI 2.5–9.6)
Tamburino, 2011 (6)663PVL ≥2Late mortalityHR = 3.79 (95% CI 1.57–9.10)
Sinning, 2012 (41)146Moderate/severe PVL1-year survivalHR = 3.9 (95% CI 2.0–7.5)HR = 2.4 (95% CI 1.0–5.4)
Unbehaun, 2012 (26)358No vs. trace vs. mild AR2-year survival66% vs. 72% vs. 67% (p = 0.77)
Kodali, 2012 (8)158Mild to severe AR2-year survivalHR = 1.75 (95% CI 1.17–2.61)Not significant
Mild to severe PVL2-year survivalHR = 2.11 (95% CI 1.43–3.10)Not significant

HR = hazard ratio; IQR = interquartile range; OR = odds ratio; other abbreviations as in Table 1.