Table 3

Change in Heart Rate and Systolic Blood Pressure Before and After Adenosine Administration

RestDuring Adenosine Infusion% Change in PRP
Nondiabetic subjects
 HR (beats/min)69 ± 1289 ± 17
 SBP (mm Hg)118 ± 18114 ± 17
 DBP (mm Hg)76 ± 770 ± 11
 PRP82 ± 15100 ± 2124 ± 23
Nonneuropathic diabetic subjects
 HR (beats/min)71 ± 1179 ± 11
SBP (mm Hg)130 ± 21129 ± 21
DBP (mm Hg)76 ± 1873 ± 13
 PRP94 ± 22105 ± 2514 ± 10
Subjects with DAN
 HR (beats/min)96 ± 1194 ± 14
 SBP (mm Hg)142 ± 25138 ± 30
 DBP (mm Hg)88 ± 1178 ± 14
 PRP128 ± 28129 ± 261 ± 10
  • Results are expressed as the mean value ± SD. HR, PRP and % change in PRP differed between groups (p = 0.0001, p = 0.0002, p = 0.02, respectively, one-way analysis of variance).

  • p < 0.01 versus nondiabetic and nonneuropathic diabetic subjects.

  • p < 0.05 versus nondiabetic and nonneuropathic diabetic subjects. DAN = diabetic autonomic neuropathy; DBP = diastolic blood pressure; HR = heart rate; PRP = pressure-rate product (HR × SBP/100); SBP = systolic blood pressure.