Table 2

Outcomes by Study and Treatment

OutcomesFRISC-IIRITA-3ICTUSCombinedHR (95% CI)p Value
SI (n = 1,235)RI (n = 1,222)SI (n = 915)RI (n = 895)SI (n = 596)RI (n = 604)SI (n = 2,746)RI (n = 2,721)
All-cause death124 (10.1%)117 (9.6%)138 (15.1%)104 (11.6%)59 (9.9%)67 (11.1%)321 (11.7%)288 (10.6%)0.90 (0.77−1.05)0.19
CV death86 (7.1%)79 (6.6%)92 (10.3%)64 (7.3%)40 (6.8%)38 (6.5%)218 (8.1%)181 (6.8%)0.83 (0.68−1.01)0.068
MI206 (17.6%)150 (12.9%)78 (8.9%)60 (6.9%)54 (9.4%)50 (8.6%)338 (12.9%)260 (10.0%)0.77 (0.65−0.90)0.001
All-cause death/MI283 (23.8%)231 (19.7%)182 (20.2%)144 (16.3%)95 (16.1%)105 (17.5%)560 (20.9%)480 (18.1%)0.85 (0.75−0.96)0.008
CV death/MI254 (21.4%)204 (17.4%)143 (16.1%)107 (12.2%)78 (13.4%)78 (13.2%)475 (17.9%)389 (14.7%)0.81 (0.71−0.93)0.002

CV = cardiovascular; other abbreviations as in Table 1.

  • Percentages are Kaplan-Meier percentages at 5 years. Including all periprocedure infarctions, the data for FRISC-II and RITA-3 are unchanged, and for ICTUS, there were 14 additional MIs in the SI strategy and 32 additional MIs in the RI strategy. In consequence, combined, there were 487 (18.3%) CV death/MIs in the SI and 420 (15.9%) in the RI groups: hazard ratio (HR): 0.86, 95% confidence interval (CI): 0.76 to 0.98, p = 0.028.