Table 5

Treatment Effect by Integer Risk Category of CV Death or MI

Risk GroupRisk ScoreTreatment GroupHR(95% CI)Risk Difference(95% CI)
SIRI
1st (low)0–4149/1,503 (10.2%)114/1,423 (8.2%)0.80 (0.63 to 1.02)–2.0% (–4.1% to 0.1%)
2nd (moderate)5–8186/912 (21.1%)155/920 (17.3%)0.81 (0.66 to 1.01)–3.8% (–7.4% to –0.1%)
3rd (high)≥9140/331 (44.1%)120/378 (33.0%)0.68 (0.53 to 0.86)–11.1% (–18.4% to –3.8%)
Total475/2,746 (17.9%)389/2,721 (14.7%)

Abbreviations as in Tables 1 and 2.

  • Risk group determined assuming patient in the SI group and calculated according to approximate thirds of risk among those experiencing CV death or MI. Percentages and risk differences are calculated from 5-year Kaplan-Meier estimates.

  • Interaction of treatment by integer risk score on the HR scale, p = 0.10.

  • Interaction of treatment by integer risk score on the risk difference scale, p < 0.0001.