Table 2

Selected Multifactorial Causes of ST

Precipitant of Stent Thrombosis
Stent factorsHypersensitivity to drug coating or polymer
Incomplete endothelialization
Stent design
Covered stents (64,65)
Patient factorsPCI for acute coronary syndrome/ST-segment elevation MI
Diabetes mellitus
Renal failure
Impaired left ventricular function
Premature cessation of dual antiplatelet therapy
Aspirin nonresponsiveness
  • Clopidogrel nonresponsiveness

  • Glycoprotein IIb/IIIa inhibitors

Prior brachytherapy
  • Malignancy

  • Saphenous vein graft disease

Lesion characteristicsLesion/stent length
Vessel/stent diameter
Complex lesions (bifurcation lesions, chronic total occlusions)
Saphenous vein graft target lesion
Procedural factorsInadequate stent expansion/sizing
Incomplete stent apposition
Stent deployment in necrotic core
Residual edge dissection

MI = myocardial infarction; PCI = percutaneous coronary intervention; ST = stent thrombosis.