Table 2

Studies With 10,000 or More Patients: VCD Versus MC

First Author (Ref. #)Year PublishedNStudy TypeEndpointComplication Ratesp Value
VCDMC
Nikolsky et al. (80)200436,066Trial and registry meta-analysisHematomaOR: 1.3495% CI: 1.01–1.79<0.05
Tavris et al. (90)2004166,680National registry (NCDR)Any VC1.10%1.70%<0.001
Tavris et al. (82)200513,878National registry (NCDR)Any VCOR: 0.9995% CI: 0.77–1.28NS
Arora et al. (86)200712,937Single-center registryAny VC2.40%4.90%<0.01
Ahmed et al. (12)200713,563Multicenter registryBleeding/VCOR: 0.7295% CI: 0.59–0.890.02
Applegate et al. (11)200835,016Single-center registryAny VC1.60%2.10%0.03
Sanborn et al. (87)200911,621ACUITY post-hocAccess site bleeding2.50%3.30%0.01
Marso et al. (1)20101,522,935National registry (NCDR)Periprocedural bleedingOR: 0.7795% CI: 0.73–0.80<0.05

ACUITY = Acute Catheterization and Urgent Intervention Triage strategY trial; CI = confidence interval; MC = manual compression; NCDR = National Cardiovascular Data Registry; NS = not significant; OR = odds ratio; VC = vascular closure; VCD = vascular closure device.