Table 3

VASP P2Y12 PRI in Clopidogrel-Treated Subjects With and Without 9 Days of PPI Coadministration

PRI (%)
PPI GroupClopidogrel AloneClopidogrel Plus PPILS Mean Difference90% CI of Difference
Lansoprazole 30 mg42.3 ± 14.646.4 ± 16.44.10.03 to 8.17
Dexlansoprazole 60 mg41.3 ± 15.443.0 ± 16.52.0−0.86 to 4.95
Esomeprazole 40 mg46.5 ± 17.358.0 ± 14.611.47.18 to 15.71
Omeprazole 80 mg47.9 ± 15.759.1 ± 17.911.06.52 to 15.56

Values are mean ± SD. An LS mean difference with a 90% CI upper boundary of >15% was pre-specified to be significant.

LS = least squares; PRI = platelet reactivity index; VASP = vasodilator-stimulated phosphoprotein; other abbreviations as in Tables 1 and 2.