Table 2

Inflammatory Markers Associated With Subtypes of Atrial Fibrillation

First Author (Ref. #)YearSubjectsAF SubtypeMarkersResults
Chung et al. (Online Ref. 6)2001131 AF
71 Controls
LAF paroxysmal, permanentCRPCRP was higher in permanent AF than paroxysmal AF
Gedikl et al. (Online Ref. 27)200784 AF
30 Controls
New onset AF
Chronic AF (persistent, permanent)
hsCRP, IL-6The hsCRP and IL-6 levels were not different in new onset and chronic AF
Liuba et al. (21)200818 AF
10 Controls
Paroxysmal, permanenthsCRP, IL-6, IL-81. hsCRP and IL-6 levels were not different in paroxysmal and permanent AF
2. IL-8 was higher in permanent AF than in paroxysmal AF
Li et al. (10)2010305 AF
150 Controls
LAF
Paroxysmal, persistent, permanent
IL-6, IL-8, IL-10,
 TNF-α, MCP-1
1. IL-6, IL-8, and MCP1 concentrations were not different in 3 subtypes of AF
2. IL-10 levels were higher in persistent and permanent AF than in paroxysmal AF
3. A graded increase in TNF-α was observed in 3 subtypes of AF
Marcus et al. (25)2010167 AF
207 Controls
Paroxysmal
Persistent
IL-6, CRP1. CRP and IL-6 levels were higher in patients with persistent AF than with paroxysmal AF after adjusting for age, sex, race, hypertension, CHF, statin, and ACEI/ARB use
2. CRP and IL-6 level did not remain higher in persistent versus paroxysmal group after adjusting for rhythm present during blood draw
Pellegrino et al. (24)201196 AF
60 Controls
LAF
Paroxysmal, persistent
CRP1. CRP levels were higher in patients with paroxysmal than with persistent AF
2. AF patients with SHD had higher CRP levels than LAF patients and control subjects

ACEI = angiotensin-converting-enzyme inhibitor; ARB = angiotensin-receptor blocker; CHF = congestive heart failure; hsCRP = high-sensitivity C-reactive protein; LAF = lone atrial fibrillation; SHD = structural heart disease; other abbreviations as in Table 1.