Table 2

Baseline and Follow-Up Chemical, Angiographic, and IVUS Parameters by Group

BaselineFollow-up
Standard
(n = 43)
Intensive
(n = 44)
p ValueStandard
(n = 43)
Intensive
(n = 44)
p Value
Cholesterol
 Total, mg/dl144.4 ± 30.8143.8 ± 26.40.92148.6 ± 34.5123.1 ± 33.40.001
 LDL-C, mg/dl82.8 ± 26.979.1 ± 25.30.5181.9 ± 27.958.4 ± 26.3<0.001
 HDL-C, mg/dl37.0 ± 10.441.6 ± 10.50.0438.4 ± 12.042.5 ± 10.20.09
 Non–HDL-C, mg/dl107.4 ± 30.3102.2 ± 25.30.39110.2 ± 33.680.6 ± 31.5<0.001
 LDL:HDL2.1 ± 0.91.9 ± 0.60.272.4 ± 1.21.5 ± 0.6<0.001
 Triglycerides, mg/dl123.2 ± 61.7107.0 ± 66.20.25138.7 ± 90.6108.9 ± 69.40.09
hs-CRP, mg/l1.7 (0.7–3.4)1.7 (0.8–3.5)0.841.9 (0.7–4.7)1.2 (0.7–2.5)0.17
Angiography and FFR
 Diameter stenosis, %79.979.60.898379.40.08
 FFR0.73 ± 0.10.73 ± 0.10.950.73 ± 0.10.75 ± 0.10.36
 FFR change0.01 ± 0.080.02 ± 0.070.49
Lesion length, mm34 (26–36)42 (32–48)0.0734 (26–37)39 (30–47)0.13
IVUS
 EEM volume, mm3290 ± 152371 ± 1660.05300 ± 155404 ± 2710.07
 Attenuated plaques, %21/43 (48.8)31/44 (70.5)0.0420/43 (46.5)30/44 (57.5)0.04
 TAV, mm3, normalized197.3 ± 61.7195.8 ± 63.30.93199.6 ± 63.9209.6 ± 74.10.57
 Plaque burden %75.675.90.8674.975.30.83
 Plaque + media, mm28.2 ± 3.58.4 ± 3.70.898.0 ± 3.58.6 ± 4.20.53

Values are mean ± SD, median (interquartile range), n/N (%), or %.

CSA = cross-sectional area; EEM = external elastic membrane; FFR = fractional flow reserve; HDL-C = high-density lipoprotein cholesterol; hs-CRP = high-sensitivity C-reactive protein; IVUS = intravascular ultrasound; LDL-C = low-density lipoprotein cholesterol; TAV = total atheroma volume.

  • Lesion length measured using near-infrared spectroscopy.