Table 3

Baseline, Follow-Up, and Change in Primary and Secondary LCBI Endpoints

Standard
(n = 34)
Intensive
(n = 36)
p Value
Baseline, median (IQR)
 LCBI4mm max356.7 (145.2 to 509.2)490.6 (363.8 to 689.7)0.01
 LCBI, lesion95.4 (29.6 to 174.6)132.4 (99.0 to 201.2)0.04
Follow-up, median (IQR)
 LCBI4mm max385.7 (139.2 to 510.9)336.1 (252.3 to 479.9)0.93
 LCBI, lesion99.9 (38.2 to 204.3)99.8 (64.2 to 159.3)0.88
Median change (95% CI)
 LCBI4mm max2.4 (−36.1 to 44.7)−149.1 (−210.9 to −42.9)0.01
 LCBI, lesion8.0 (−7.7 to 22.1)−22.5 (−59.2 to −3.5)0.02
Median percent change (95% CI)
 LCBI4mm max−0.6 (−22.0 to 12.4)−32.2 (−40.4 to −12.4)0.02
 LCBI, lesion5.4 (−19.6 to 34.1)−24.4 (−43.6 to −2.0)0.03
Any LCBI regression, %
 LCBI4mm max50.080.60.01
 LCBI lesion44.169.40.03

IQR = interquartile range; LCBI4mm max = lipid-core burden index at the 4-mm maximal segment.

  • Table includes LCBI comparisons for study participants with values at both baseline and staged time points (n = 70).

  • p Values from analysis of covariance models on rank-transformed data controlling for baseline LCBI. All confidence intervals (CI) are distribution free.