Table 4

Univariate Predictors of IVUS Disease Burden (n = 654)

ParametersPercent Atheroma VolumeTotal Atheroma VolumePercent Abnormal Cross Sections
β Coeff. (95% CI)p Valueβ Coeff. (95% CI)p Valueβ Coeff. (95% CI)p Value
Age1.2 (−0.2 to 2.5)0.091.4 (0.1 to 2.7)0.040.7 (−0.6 to 2.0)0.30
Male gender (n = 456)59.6 (31.7 to 87.5)<0.000190.3 (63 to 117.6)<0.000165.7 (38.7 to 92.8)<0.0001
Non-white race (n = 74)40.5 (0.9 to 80.2)0.04552.5 (12.9 to 92.1)0.00921.9 (−16.9 to 60.6)0.27
BMI−1.7 (−3.8 to 0.4)0.111.7 (−0.4 to 3.8)0.12−0.1 (−2.2 to 1.9)0.91
Current smoker (n = 182)19.4 (−9.5 to 48.3)0.19−8.2 (−37.2 to 20.9)0.5815.5 (−12.8 to 43.7)0.29
Systolic BP0.4 (−0.3 to 1.1)0.260.8 (0.1 to 1.5)0.030.4 (−0.3 to 1.1)0.24
Diastolic BP0.4 (−0.8 to 1.7)0.521.6 (0.4 to 2.8)0.010.7 (−0.5 to 1.9)0.25
Total cholesterol−0.3 (−0.7 to 0.1)0.13−0.3 (−0.7 to 0.1)0.16−0.1 (−0.5 to 0.3)0.64
LDL cholesterol−0.1 (−0.6 to 0.3)0.58−0.2 (−0.7 to 0.3)0.370 (−0.5 to 0.4)0.94
HDL cholesterol−1 (−2.3 to 0.1)0.07−1.9 (−3.1 to −0.7)0.002−1.3 (−2.5 to −0.2)0.03
Triglycerides−0.1 (−0.2 to 0.1)0.490 (−0.1 to 0.2)0.660 (−0.1 to 0.2)0.73
Apo B−0.3 (−0.8 to 0.3)0.36−0.2 (−0.7 to 0.4)0.580.1 (−0.5 to 0.6)0.79
CRP−2.2 (−13.9 to 9.6)0.72−4.2 (−16 to 7.6)0.48−2.9 (−14.3 to 8.6)0.63
Diabetes (n = 128)60.3 (28.2 to 92.3)0.000237.2 (4.8 to 69.6)0.0234.7 (3.2 to 66.2)0.03
Hypertension (n = 439)28.8 (1.5 to 56.1)0.0430.5 (3.2 to 57.8)0.0319 (−7.7 to 45.6)0.16
Prior MI (n = 228)28.2 (1.8 to 54.6)0.045.9 (−20.7 to 32.4)0.676 (−19.9 to 31.8)0.65
Angina (n = 587)11.6 (−29.9 to 53)0.58−26.2 (−67.6 to 15.2)0.21−11.1 (−51.4 to 29.3)0.59
Prior procedure (n = 447)88.3 (61.4 to 115.1)<0.000142.3 (14.5 to 70.1)0.00339.4 (12.4 to 66.5)0.004
Prior revascularization (n = 438)87.2 (60.5 to 113.8)<0.000142.3 (14.8 to 69.8)0.00338 (11.2 to 64.8)0.006
Stroke (n = 22)121.6 (42.1 to 201)0.00343.1 (−37.2 to 123.2)0.2991.2 (13.5 to 168.9)0.02
Metabolic syndrome (n = 268)1.8 (−24.2 to 27.7)0.8921.1 (−4.8 to 47)0.118.1 (−17.1 to 33.4)0.53

Apo B = apolipoprotein B; BMI = body mass index; BP = blood pressure; CRP = C-reactive protein; HDL = high-density lipoprotein; IVUS = intravascular ultrasound; LDL = low-density lipoprotein; MI = myocardial infarction.

  • β coefficient (β Coeff.), 95% confidence interval (CI) of β Coeff., and p value are based on univariate least-square regression analysis using rank-transformed IVUS parameters as the dependent variable.