Table 4

Mortality Odds Ratios in Pair-Wise Treatment Comparisons

AnalysisNTG (n = 6,055) vs. MIL (n = 1,660)NTG (n = 5,713) vs. DOB (n = 3,478)NES (n = 4,663) vs. MIL (n = 1,534)NES (n = 4,270) vs. DOB (n = 3,301)NES (n = 4,402) vs. NTG (n = 5,668)DOB (n = 3,656) vs. MIL (n = 1,496)
Unadjusted0.34 (0.28–0.41)0.24 (0.20–0.28)0.53 (0.44–0.64)0.37 (0.32–0.44)1.64 (1.38–1.94)1.39 (1.15–1.68)
Adjusted for covariates0.69 (0.54–0.88)0.46 (0.38–0.57)0.59 (0.48–0.73)0.47 (0.39–0.56)0.95 (0.78–1.16)1.27 (1.04–1.56)§
Adjusted for covariates and propensity score0.69 (0.53–0.89)0.46 (0.37–0.57)0.59 (0.48–0.73)0.47 (0.39–0.56)0.94 (0.77–1.16)1.24 (1.03–1.55)§

Hosmer-Lemeshow goodness-of-fit test not significant at 5% levels for the models adjusted for risk factors and/or propensity, except for covariate-adjusted NTG vs. DOB comparison, where p = 0.04. Area under the receiver operator curve = 0.70 or higher. Because of multiple pair-wise comparisons, only p values <0.008 were considered significant using Bonferroni correction.

DOB = dobutamine; HF = heart failure; LVEF = left ventricular ejection fraction; MIL = milrinone; NES = nesiritide; NTG = nitroglycerin; OR = odds ratio; VTF = ventricular tachycardia/fibrillation; other abbreviations as in Table 1.

  • Patients taking both medications were excluded from each pair-wise analysis.

  • p < 0.005.

  • p = 0.58.

  • § p = 0.021 for covariate adjustment and 0.027 for covariate and propensity score adjustment.

  • Covariates include age, gender, SBP, DBP, BUN, creatinine, sodium, heart rate, and dyspnea.

  • Covariates included in the propensity score by treatment comparison are: NES vs. DOB: SBP, sodium, BUN, creatinine, age, weight, LVEF, edema; NES vs. MIL: SBP, age, LVEF, dyspnea, weight; NTG vs. DOB: SBP, sodium, BUN, heart rate, LVEF, symptom duration; NTG vs. MIL: SBP, BUN, LVEF, symptom duration, dyspnea, QRS >120 ms, previous revascularization; NES vs. NTG: SBP, BUN, creatinine, LVEF, symptom duration, edema, previous HF, QRS >120 ms; DOB vs. MIL: SBP, age, hemoglobin, heart rate, dyspnea, VTF.