Table 2

Updated Classification for Drug- and Toxin-Induced PAH

DefinitePossible
AminorexCocaine
FenfluraminePhenylpropanolamine
DexfenfluramineSt. John's wort
Toxic rapeseed oilChemotherapeutic agents
BenfluorexInterferon α and β
SSRIsAmphetamine-like drugs
LikelyUnlikely
AmphetaminesOral contraceptives
L-TryptophanEstrogen
MethamphetaminesCigarette smoking
Dasatinib
  • Nice 2013.

  • Selective serotonin reuptake inhibitor (SSRIs) have been demonstrated as a risk factor for the development of persistent pulmonary hypertension in the newborn (PPHN) in pregnant women exposed to SSRIs (especially after 20 weeks of gestation). PPHN does not strictly belong to Group 1 (pulmonary arterial hypertension [PAH]) but to a separated Group 1. Main modification to the previous Danapoint classification are in bold.