Table 1

Baseline Characteristics of Patients Included in Phase 1, By Country and Overall

OverallArgentinaBrazilParaguayItalySpain
n(%) 2,118528 (24.93)113 (5.34)62 (2.93)654 (30.9)761 (35.93)
Characteristics
 Male1,700 (80.26)437 (82.8)81 (71.7)49 (79.0)491 (75.1)642 (84.4)
 Age, yrs64.01 ± 11.2860.4 ± 10.362.3 ± 10.461.5 ± 9.0867.2 ± 11.464.2 ± 11.4
 ≤50262 ± 12.3793 ± 17.913 ± 11.58 ± 12.950 ± 7.6698 ± 13.1
 51–701,220 ± 57.6342 ± 65.672 ± 63.743 ± 69.4341 ± 52.2422 ± 56.4
 >70615 ± 29.0486 ± 16.528 ± 24.811 ± 17.7262 ± 40.1228 ± 30.5
Clinical
 Age at date of AMI60.45 ± 11.2757.7 ± 1061.2 ± 10.661.3 ± 9.0563.3 ± 11.559.6 ± 11.6
 Previous AMI history281 (13.27)67 (12.8)22 (19.5)14 (22.6)96 (14.7)82 (12.1)
 Previous angina history612 (28.9)205 (39.1)33 (29.2)35 (56.5)206 (31.5)133 (19.6)
 Previous syncope history94 (4.44)13 (2.49)8 (7.08)0 (0)55 (8.41)18 (2.65)
 Previous ventricular tachycardia94 (4.44)17 (3.24)5 (4.42)2 (3.23)44 (6.73)26 (3.82)
 Previous pacemaker46 (2.17)6 (1.15)0 (0)0 (0)28 (4.28)12 (1.76)
 Previous ICD46 (2.17)9 (1.72)1 (0.885)0 (0)20 (3.06)16 (2.38)
 Previous hypertension history1,328 (62.7)364 (69.5)84 (74.3)44 (71)410 (62.7)426 (60.9)
 Previous dyslipidemia history1,249 (58.97)319 (60.9)74 (65.5)30 (48.4)385 (58.9)441 (63.0)
 Previous diabetes history554 (26.16)119 (22.8)35 (31.0)19 (30.6)159 (24.3)222 (31.8)
 Previous SBP, mm Hg129.05 ± 18.39125 ± 17.1129 ± 21.9110 ± 15.8131 ± 16.3131 ± 19.4
 Previous DBP, mm Hg75.93 ± 10.0475.6 ± 9.8677 ± 12.767.9 ± 8.7178.5 ± 8.3774.3 ± 10.6
 Normal <120 or <80 mm Hg464 ± 21.91144 ± 27.534 ± 30.139 ± 62.986 ± 13.3161 ± 22.7
 Pre-hypertension 120–139 or 80–89 mm Hg991 ± 46.79265 ± 50.645 ± 39.817 ± 27.4349 ± 53.8315 ± 44.4
 Hypertension602 ± 28.42115 ± 21.934 ± 30.16 ± 9.68214 ± 33233 ± 32.9
 BMI, kg/m227.51 ± 4.5728 ± 5.0527.5 ± 4.6527.8 ± 4.1827 ± 4.3427.6 ± 4.36
 Normal (healthy weight) <25 kg/m2618 ± 29.18149 ± 28.740 ± 35.415 ± 24.2235 ± 36179 ± 27.2
 Overweight from 25 to 30 kg/m2890 ± 42.02211 ± 40.644 ± 38.934 ± 54.8285 ± 43.6316 ± 48.1
 Obese >30 kg/m2497 ± 23.47160 ± 30.829 ± 25.713 ± 21133 ± 20.4162 ± 24.7
 s323 (1.09)5 (0.954)1 (0.885)2 (3.23)10 (1.53)5 (0.711)
 History of pulmonary disease28 (1.32)5 (0.954)1 (0.885)4 (6.45)13 (1.99)5 (0.711)
 History of chronic disease125 (5.9)19 (3.63)3 (2.65)2 (3.23)59 (9.02)42 (5.96)
 History of renal disease102 (4.82)19 (3.63)6 (5.31)2 (3.23)47 (7.19)28 (3.97)
 History of cancer78 (3.68)7 (1.34)2 (1.77)0 (0)27 (4.13)42 (5.96)
 Comorbidity342 (16.15)50 (9.47)12 (10.6)8 (12.9)120 (18.3)152 (20.0)
Socioeconomic
 Distance to the nearest medical center, km5.9 ± 21.710.4 ± 37.43.8 ± 6.85.5 ± 8.86.7 ± 14.11.5 ± 4.5
 ≤10 km1,656 ± 78.19441 ± 84.5100 ± 88.549 ± 79520 ± 80546 ± 97.2
 >10 km253 ± 11.9581 ± 15.513 ± 11.513 ± 21130 ± 2016 ± 2.85
 % Insurance coverage87.3 (30.71)63.2 (46.9)96.9 (13.8)85.5 (35.5)93.5 (17.2)99.5 (6.7)
 <50%197 (9.3)181 (34.9)1 (0.885)9 (14.5)3 (0.459)3 (0.45)
 ≥50%1,815 (85.69)337 (65.1)112 (99.1)53 (85.5)650 (99.5)663 (99.5)
Educational level
 Illiterate59 (2.79)5 (0.958)5 (4.42)0 (0)18 (2.75)31 (4.54)
 Others1,975 (93.25)517 (99)108 (95.6)62 (100.0)636 (97.2)652 (95.5)
Occupation
 Professionals440 (20.77)86 (16.4)4 (3.57)8 (12.9)104 (15.9)238 (34.7)
 Others1,597 (75.4)438 (83.6)108 (96.4)54 (87.1)549 (84.1)448 (65.3)
Risk factors
 Smoker319 (15.06)103 (19.9)17 (15.0)17 (27.4)85 (13.0)97 (14.0)
 Former smoker855 (40.37)184 (35.5)66 (58.4)21 (33.9)278 (42.6)306 (44.1)
 Family history of CV diseases641 (30.26)160 (30.5)53 (46.9)28 (45.2)245 (37.5)155 (22.3)
 Sedentary905 (42.73)323 (61.6)65 (57.5)40 (64.5)278 (42.5)199 (28.6)
 Alcohol646 (30.5)97 (18.6)30 (26.5)20 (32.3)299 (45.7)200 (28.7)
Baseline treatment
 Aspirin1,917 (90.51)480 (97.2)111 (99.1)60 (100.0)606 (92.9)660 (95.4)
 Antiplatelets959 (45.28)277 (56.0)55 (49.1)53 (88.3)294 (45.1)280 (40.1)
 Statin1,934 (91.31)475 (96.5)111 (99.1)60 (100)614 (94.3)674 (97.1)
 Beta-blocker1,740 (82.15)454 (92.1)105 (93.8)57 (96.6)546 (83.9)578 (84.4)
 ACEI1,370 (64.68)370 (75.1)78 (69.6)46 (78.0)469 (72.0)407 (60.6)
 ARB337 (15.91)87 (18.1)29 (26.1)8 (13.6)93 (14.3)120 (19.1)
 Total number of pills (and others)/day7.25 ± 2.856.89 ± 2.158.95 ± 2.688.87 ± 1.726.55 ± 2.527.73 ± 3.38
Depression
 PHQ-9 score 5–9 minimal symptoms661 (31.21)0 (0)0 (0)0 (30.6)311 (48.5)350 (48.4)
 PHQ-9 score 10–14 minor depression936 (44.19)215 (41)41 (36.3)19 (30.6)311 (48.5)350 (48.4)
 PHQ-9 score 15–19 major depression, moderately severe693 (32.72)194 (37)31 (27.4)22 (35.5)208 (32.4)238 (32.9)
 PHQ-9 score ≥20 major depression, severe435 (20.54)116 (22.1)41 (36.3)21 (33.9)122 (19.0)135 (18.7)
 Stress, yes1,583 (74.74)403 (76.5)70 (61.9)44 (71.0)457 (70.1)609 (81.6)
Center private514 (24.27)402 (81.2)112 (100.0)0 (0)0 (0)0 (0)
Center public1,503 (70.96)93 (18.8)0 (0)60 (100.0)652 (100.0)698 (100.0)
Cardiologist1,663 (78.52)495 (100.0)0 (0)60 (100.0)652 (100.0)456 (65.3)
General treatment354 (16.71)0 (0)112 (100.0)0 (0)0 (0)242 (34.7)
 <4 pills68 (3.21)12 (2.42)0 (0)0 (0)29 (4.45)27 (3.87)
 ≥4–9 pills1,181 (55.76)324 (65.5)37 (33.0)14 (23.3)442 (67.9)364 (52.1)
 ≥10 pills767 (36.21)159 (32.1)75 (67.0)46 (76.7)180 (27.6)307 (44.0)
Complex treatment, yes208 (9.82)34 (6.87)4 (3.57)15 (25.0)64 (9.82)91 (13)
Time from AMI, months42.96 ± 66.9333.8 ± 63.915.5 ± 162.17 ± 445.9 ± 6854.9 ± 72.4
 <6 months595 (28.09)222 (50.2)14 (12.8)52 (88.1)149 (26.3)158 (28.0)
 6 months to 1 yr239 (11.28)59 (13.3)30 (27.5)5 (8.47)59 (10.4)86 (15.2)
 1–2 yrs446 (21.06)68 (15.4)57 (52.3)2 (3.39)216 (38.1)103 (18.2)
 >2 yrs462 (21.81)93 (21.0)8 (7.34)0 (0)143 (25.2)218 (38.6)

Values are n (%) or mean ± SD.

ACEI = angiotensin-converting enzyme inhibitors; AMI = acute myocardial infarction; ARB = angiotensin-II receptor blockers; BMI = body mass index; CV = cardiovascular; DBP = diastolic blood pressure; ICD = implantable cardioverter-defibrillator; PHQ-9 = Patient Health Questionnaire-9; SBP = systolic blood pressure.