Table 1

TGRLs and Inflammation

EndotheliumVCAM-1 transcription and expression
 Monocyte infiltration
 Increased permeability facilitates VLDL remnant uptake
BloodLipolytic products (oxidized fatty acids)
 ROS-mediated AP-1 up-regulation of IL-1, IL-6, IL-8, VEGF, and PPAR-gamma
Intestinal microfloraLPS transport into blood via dietary lipids

AP = activator protein; IL = interleukin; LPS = lipopolysaccharide; PPAR = peroxisome proliferator-activated receptor; ROS = reactive oxygen species; TGRL = triglyceride-rich lipoprotein; VCAM = vascular cell adhesion molecule; VEGF = vascular endothelial cell growth factor; VLDL = very low-density lipoprotein.