Table 10

Common Medication Dosage for Rate Control of AF

Intravenous AdministrationUsual Oral Maintenance Dose
Beta blockers
 Metoprolol tartrate2.5–5.0 mg IV bolus over 2 min; up to 3 doses25–100 mg BID
 Metoprolol XL (succinate)N/A50–400 mg QD
 AtenololN/A25–100 mg QD
 Esmolol500 mcg/kg IV bolus over 1 min, then 50–300 mcg/kg/min IVN/A
 Propranolol1 mg IV over 1 min, up to 3 doses at 2-min intervals10–40 mg TID or QID
 NadololN/A10–240 mg QD
 CarvedilolN/A3.125–25 mg BID
 BisoprololN/A2.5–10 mg QD
Nondihydropyridine calcium channel antagonists
 Verapamil0.075−0.15 mg/kg IV bolus over 2 min; may give an additional 10.0 mg after 30 min if no response, then 0.005 mg/kg/min infusion180–480 mg QD (ER)
 Diltiazem0.25 mg/kg IV bolus over 2 min, then 5−15 mg/h120–360 mg QD (ER)
Digitalis glycosides
 Digoxin0.25 mg IV with repeat dosing to a maximum of 1.5 mg over 24 h0.125–0.25 mg QD
 Amiodarone300 mg IV over 1 h, then 10–50 mg/h over 24 h100–200 mg QD

AF indicates atrial fibrillation; BID, twice daily; ER, extended release; IV, intravenous; N/A, not applicable; QD, once daily; QID, 4 times a day; and TID, 3 times a day.

  • Multiple dosing schemes exist for the use of amiodarone.