Table 1

Patient Characteristics

Main StudyBiomarker Substudy
By TreatmentAll Patients (N = 4,385)By TreatmentBy Recurrent Stroke Event
Atorvastatin (n = 2,365)Placebo (n = 2,366)Atorvastatin (n = 2,191)Placebo (n = 2,194)With Event (n = 544)Without Event (n = 3,841)p Value
Age, yrs63.0 ± 0.262.5 ± 0.262.8 ± 0.263.0 ± 0.262.5 ± 0.265.8 ± 0.562.3 ± 0.2<0.0001
Male1,427 (60.3)1,396 (59.0)2,625 (59.9)1,322 (60.3)1,303 (59.4)362 (66.5)2,263 (58.9)0.0007
Risk factor
 Current smoker452 (19.1)456 (19.3)836 (19.1)412 (18.8)424 (19.3)108 (19.9)728 (19.0)0.3799
 Hypertension1,476 (62.4)1,452 (61.4)2,703 (61.6)1,359 (62.0)1,344 (61.3)357 (65.6)2,346 (61.1)0.0412
 DM395 (16.7)399 (16.9)737 (16.8)363 (16.6)374 (17.0)135 (24.8)602 (15.7)<0.0001
Lipids, mg/dl
 LDL-C132.7 ± 0.5133.7 ± 0.5133.3 ± 0.4132.7 ± 0.5133.9 ± 0.5133.6 ± 1.1133.2 ± 0.40.5856
 Total cholesterol211.4 ± 0.6212.3 ± 0.6211.8 ± 0.4211.3 ± 0.6212.2 ± 0.6211.1 ± 1.2211.9 ± 0.50.6249
 Triglycerides144.2 ± 1.9143.2 ± 1.4143.1 ± 1.2143.5 ± 2.0142.7 ± 1.5145.2 ± 2.9142.8 ± 1.40.1998
 HDL-C50.0 ± 0.350.0 ± 0.350.0 ± 0.250.1 ± 0.349.9 ± 0.348.4 ± 0.550.2 ± 0.20.0077
OxPL-apoB, nmol/l12.2 (6.7–18.7)12.0 (6.8–18.5)12.4 (6.6–18.9)15.5 (11.0–21.3)11.6 (6.3–18.2)<0.0001

Values are mean ± SD or median (interquartile range) for continuous variables or n (%) for categorical variables.

DM = diabetes mellitus; HDL-C = high-density lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol; OxPL-apoB = oxidized phospholipids on apolipoprotein B-100.

  • p value for patients in the biomarker subgroup who experienced an event versus those that did not.