Table 4

Neurocognitive Assessments

Control ArmDevice Armp Value
Change From BaselineChange From Baseline
Attention
 Baseline−0.17 ± 0.88 (117)NA−0.14 ± 0.96 (117)NANA
 2–7 days post-TAVR−0.28 ± 1.10 (65)−0.01 ± 0.59 (65)−0.50 ± 1.02 (65)−0.32 ± 0.70 (65)0.0334
 30-day follow-up0.03 ± 0.88 (92)0.14 ± 0.51 (92)−0.14 ± 0.93 (93)0.03 ± 0.55 (93)0.1778
 90-day follow-up0.11 ± 0.87 (76)0.23 ± 0.55 (76)0.06 ± 0.87 (77)0.20 ± 0.49 (77)0.6103
Executive function
 Baseline−1.36 ± 1.36 (117)NA−1.28 ± 1.3 (117)NANA
 2–7 days post-TAVR−1.36 ± 1.36 (63)0 ± 1 (63)−1.70 ± 1.55 (65)−0.36 ± 1.19 (65)0.0865
 30-day follow-up−0.99 ± 1.34 (91)0.25 ± 0.86 (91)−1.20 ± 1.40 (93)0.14 ± 0.86 (93)0.4692
 90-day follow-up−0.79 ± 1.21 (76)0.39 ± 0.86 (76)−0.94 ± 1.16 (77)0.32 ± 0.79 (77)0.4585
Processing speed
 Baseline−0.23 ± 0.95 (117)NA−0.24 ± 0.91 (117)NANA
 2–7 days post-TAVR−0.47 ± 0.87 (63)−0.05 ± 0.38 (63)−0.51 ± 0.94 (65)−0.06 ± 0.5 (65)0.9698
 30-day follow-up−0.01 ± 0.86 (90)0.12 ± 0.39 (90)−0.11 ± 1.00 (92)0.14 ± 0.43 (92)0.5470
 90-day follow-up0.14 ± 0.81 (76)0.27 ± 0.43 (76)−0.05 ± 0.86 (77)0.21 ± 0.46 (77)0.7272
Verbal memory
 Baseline−0.64 ± 1.07 (117)NA−0.85 ± 0.94 (117)NANA
 2–7 days post-TAVR−1.06 ± 1.06 (66)−0.63 ± 0.79 (66)−1.34 ± 1.3 (66)−0.70 ± 1.03 (66)0.8534
 30-day follow-up−0.88 ± 1.18 (91)−0.32 ± 0.80 (91)−1.09 ± 1.13 (93)−0.28 ± 0.85 (93)0.4644
 90-day follow-up−0.61 ± 1.11 (76)−0.13 ± 0.78 (76)−0.86 ± 1.05 (77)−0.02 ± 0.78 (77)0.2933
Visual memory
 Baseline−0.72 ± 0.96 (117)NA−0.83 ± 0.85 (115)NANA
 2–7 days post-TAVR−0.70 ± 1.01 (65)0.06 ± 0.86 (65)−0.87 ± 0.94 (66)−0.19 ± 0.96 (65)0.1340
 30-day follow-up−1.02 ± 1.03 (92)−0.36 ± 0.79 (92)−1.28 ± 0.94 (93)−0.46 ± 0.91 (92)0.4282
 90-day follow-up−0.53 ± 0.98 (76)0.12 ± 0.81 (76)−0.58 ± 0.98 (77)0.17 ± 0.86 (77)0.6942
Mental status
 Baseline26.07 ± 3.32 (116)NA26.12 ± 2.95 (114)NANA
 2–7 days post-TAVR26.02 ± 2.81 (62)−0.25 ± 2.47 (61)25.41 ± 3.58 (64)−0.73 ± 2.95 (63)NA
 30-day follow-up26.82 ± 2.74 (89)0.52 ± 2.55 (89)26.24 ± 2.84 (92)0.41 ± 2.67 (91)NA
 90-day follow-up27.24 ± 2.47 (76)0.96 ± 2.42 (76)26.56 ± 2.60 (77)0.30 ± 2.76 (76)NA
Depression
 Baseline2.70 ± 2.28 (116)NA3.33 ± 2.62 (114)NANA
 2–7 days post-TAVR2.26 ± 2.53 (62)−0.48 ± 1.41 (61)2.77 ± 2.83 (64)−0.57 ± 2.12 (63)NA
 30-day follow-up2.07 ± 2.14 (89)−0.73 ± 1.57 (89)2.38 ± 2.43 (91)−0.68 ± 2.02 (90)NA
 90-day follow-up2.37 ± 2.75 (76)−0.49 ± 2.16 (76)2.53 ± 2.66 (77)−0.75 ± 2.22 (76)NA
Overall composite score
 Baseline−0.63 ± 0.79 (117)NA−0.66 ± 0.75 (117)NANA
 2–7 days post-TAVR−0.81 ± 0.93 (66)−0.16 ± 0.58 (66)−1.00 ± 0.95 (66)−0.33 ± 0.65 (66)0.1894
 30-day follow-up0.59 ± 0.79 (92)−0.03 ± 0.37 (92)−0.77 ± 0.82 (93)−0.09 ± 0.44 (93)0.4207
 90-day follow-up−0.34 ± 0.72 (76)0.18 ± 0.35 (76)−0.47 ± 0.76 (77)0.18 ± 0.38 (77)0.9409

Abbreviations as in Table 1.

Values are mean ± SD (n).

  • p values calculated on the basis of a model adjusted for education, baseline Geriatric Depression Score, and baseline Mini-Mental State Examination score.

  • Raw score provided for mental state and depression.