Table 1

Baseline Characteristics by SYNTAX Score

Low SYNTAX Score (≤22) (n = 1,219)Mid/High SYNTAX Score (≥23) (n = 331)p Value
Age at study entry, yrs62.0 (55.7–68.5)63.3 (56.7–69.6)0.032
Male68.7 (837)78.9 (261)0.001
Race/ethnicity
 White non-Hispanic65.5 (799)69.2 (229)0.286
 Black non-Hispanic17.6 (214)13.3 (44)
 Hispanic11.5 (140)11.2 (37)
 Asian/other non-Hispanic5.4 (66)6.3 (21)
Insulin-providing assignment49.7 (606)48.9 (162)0.804
Sitting systolic BP130.0 (118.7–143.3)131.3 (116.7–143.3)0.988
Sitting diastolic BP75.3 (68.7–80.7)74.0 (67.3–80.0)0.319
BMI, kg/m231.2 (27.5–35.0)30.3 (27.1–33.4)0.009
Hypertension requiring therapy81.8 (985)80.6 (261)0.605
History of cigarette smoking64.1 (779)64.2 (212)0.952
History of MI21.8 (261)33.4 (109)0.001
History of CHF requiring therapy5.6 (68)4.2 (14)0.328
Duration of DM8.1 (3.4–14.6)8.7 (4.0–16.0)0.131
HbA1c %7.30 (6.50–8.60)7.30 (6.40–8.45)0.717
LDL, mg/dl93.0 (74.0–116.0)93.0 (74.0–118.0)0.894
HDL, mg/dl37.0 (31.0–43.0)36.0 (32.0–42.0)0.451
Total cholesterol, mg/dl165.0 (141.0–193.0)165.5 (142.0–193.0)0.913
eGFR (MDRD algorithm), ml/min/1.73 m277.1 (63.9–91.7)76.8 (61.1–93.5)0.706
Currently taking insulin26.9 (327)24.2 (80)0.319
Cerebrovascular accident or TIA8.7 (106)9.5 (31)0.684
Chronic renal dysfunction2.1 (26)2.5 (8)0.733
Any major ECG abnormalities28.3 (335)29.6 (96)0.631
Baseline Q waves10.3 (125)12.1 (40)0.338
Baseline ST-segment depression1.8 (22)2.7 (9)0.292
Baseline ST-segment elevation4.8 (58)5.1 (17)0.776
Site: LVEF <50%14.7 (174)18.8 (61)0.067
Number of vessels with lesions ≥50%
 145.2 (550)14.5 (48)0.001
 235.8 (436)40.2 (133)
 319.0 (231)45.3 (150)
Number of lesions4.0 (3.0–6.0)6.0 (4.0–7.0)0.001
Lesions ≥50% stenosis2.0 (1.0–3.0)3.0 (2.0–5.0)0.001
Myocardial jeopardy40.0 (24.0–58.0)65.0 (48.0–76.0)0.001
Proximal LAD ≥50% stenosis9.8 (119)19.6 (65)0.001
Total occlusions44.2 (161)55.6 (110)0.010

Values are median (interquartile range) or % (n).

BMI = body mass index; BP = blood pressure; CHF = congestive heart failure; DM = diabetes mellitus; ECG = electrocardiogram; eGFR = estimated glomerular filtration rate; HbA1c = glycosylated hemoglobin; HDL = high-density lipoprotein; LAD = left anterior descending; LDL = low-density lipoprotein; LVEF = left ventricular ejection fraction; MDRD = Modification of Diet in Renal Disease; MI = myocardial infarction; SYNTAX = Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery; TIA = transient ischemic attack.