Table 5

Correlation Between Low-Density Lipoprotein Cholesterol Determined by Beta Quantification and Calculated by Friedewald Equation

Absolute Difference vs. Calculated Values (mg/dl)% Difference vs. Calculated Values
LDL-C <15 mg/dl as determined by beta quantification (n = 259)
 Median−3.0−27.3
 Interquartile range−6.0 to 0.8−54.5 to 5.6
 Minimum/maximum−14/160−100/4,000
LDL-C ≥15 to <25 mg/dl as determined by beta quantification (n = 940)
 Median−3.5−17.2
 Interquartile range−7.0 to 0.0−35.7 to 0.0
 Minimum/maximum−24/26−100/112

Absolute difference is defined as (calculated LDL-C − measured LDL-C). Percentage difference is defined as (calculated LDL-C − measured LDL-C)/measured LDL-C × 100. Data are pooled from phase 3 studies.

LDL-C = low-density lipoprotein cholesterol.