Table 3

Association of CAD Loci With Other Diseases or Traits

LocusLocus NameDisease or TraitDisease or Trait Lead SNPp ValueDirectionr2 (CAD Lead and Disease or Trait Lead)
New Loci
6p21C2Systemic lupus erythematosusrs31303429.3 × 10−7+0.87
Primary biliary cirrhosisrs31349541 × 10−5+0.86
Multiple sclerosisrs31349543.2 × 10−90.86
11p15MRVI1-CTR9Bipolar disorder and schizophreniars20183681 × 10−6+0.96
12q13LRP1Migrainers111721134.3 × 10−9Same SNP
Lung function (FEV1/FVC)rs111721131.2 × 10−8+Same SNP
Cervical artery dissectionrs111721133 × 10−7Same SNP
12q24SCARB1Lp-PLA2 activityrs110578416.1 × 10−14+0.92
Circulating vitamin E levelsrs110578308.2 × 10−9+Same SNP
Lp-PLA2 massrs108467446.8 × 10−6+0.94
Known Loci
1p32SORT1Lp-PLA2 activityrs75284191.3 × 10−17+0.9
Metabolic syndrome domains (Atherogenic dyslipidemia–PC1)rs127403748 × 10−16+Same SNP
Lp-PLA2 massrs75284197.1 × 10−5+0.9
1q21IL6RC-reactive proteinrs48456254.2 × 10−7+Same SNP
2p21ABCG5-ABCG8Serum phytosterolrs42457912.2 × 10−70+1
2p11VAMP5-VAMP8-GGCXProstate cancerrs101874242.7 × 10−150.87
2q33WDR12Cerebral white matter hyperintensities burdenrs67053305.7 × 10−5+1
3q22MRASCoronary artery calcificationrs23063742.7 × 10−5+1
4q12REST-NOA1Heightrs170819356.7 × 10−17+0.95
4q31EDNRACarotid intima media thicknessrs18784067 × 10−12+Same SNP
Intracranial aneurysmrs68422412.4 × 10−9+0.94
6p24PHACTR1Coronary artery calcificationrs93493794 × 10−22+Same SNP
Cervical artery dissectionrs93493791 × 10−11Same SNP
Migrainers93493795 × 10−8Same SNP
Pulse wave velocityrs77506795.4 × 10−5+1
6q25LPALipoprotein (a)rs37982201.6 × 10−49+Same SNP
Colorectal cancerrs77582295.6 × 10−90.85
7p21HDAC9Stroke (large vessel stroke)rs119840411.9 × 10−11+1
7q227q22Endometriosisrs109535413.2 × 10−5+Same SNP
8q24TRIB1Metabolic syndrome domains (Atherogenic dyslipidemia–PC1)rs29540211.2 × 10−11+Same SNP
Adiponectin levelsrs29540211.8 × 10−5+Same SNP
Serum creatininers29540212.3 × 10−5+Same SNP
9p21CDKN2BAS1Coronary artery calcificationrs13330493.3 × 10−24+0.97
Abdominal aortic aneurysmrs23832071.9 × 10−8+0.91
Ankle brachial indexrs107572692.7 × 10−9+0.9
Stroke (large vessel stroke)rs23832072.4 × 10−6+0.91
Intracranial aneurysmrs107333764 × 10−12+0.94
9q34ABOAlkaline phosphatase in plasmars5794593 × 10−123+Same SNP
Activated partial thromboplastin timers5794591.7 × 10−74+Same SNP
Soluble P-selectinrs5794591.9 × 10−41+Same SNP
Soluble E-selectinrs5794591.3 × 10−29+Same SNP
Plasma carcinoembryonic levelsrs5794593 × 10−21+Same SNP
Red blood cell countrs5794599.3 × 10−18+Same SNP
Hemoglobinrs5794591.4 × 10−15+Same SNP
Hematocritrs5794597.6 × 10−14+Same SNP
Interleukin-6 levelsrs5794593.6 × 10−13+Same SNP
Circulating galectin-3 levelsrs5794591.9 × 10−10+Same SNP
Factor XIII antigenrs5794592.3 × 10−8+Same SNP
von Willebrand factorrs6510071 × 10−161+1
Venous thromboembolismrs4958282 × 10−17+1
Serum alkaline phosphatase levelsrs6510071 × 10−56+1
Ferritin levelsrs6510071 × 10−8+1
Soluble ICAM-1rs5076663 × 10−91+0.83
10q24CYP17A1-CNNM2-NT5C2Intracranial aneurysmrs124134091.2 × 10−9+Same SNP
Schizophreniars111915801.7 × 10−9+1
Autism spectrum disorderrs111914541.4 × 10−8+1
Parkinson's diseasers171151007.4 × 10−8+0.9
11q23ZNF259-APOA5-APOA1Metabolic syndrome domains (Atherogenic dyslipidemia–PC2)rs9641841.8 × 10−12+Same SNP
Vitamin E levelsrs9641847.8 × 10−12+Same SNP
Lp-PLA2 activityrs9641848.4 × 10−11+Same SNP
Metabolic syndrome domains (Atherogenic dyslipidemia–PC1)rs9641841.2 × 10−10+Same SNP
12q24SH2B3Selective immunoglobulin A deficiencyrs31845045.6 × 10−31+Same SNP
Type 1 diabetesrs31845042.8 × 10−27+Same SNP
Celiac diseasers31845045.4 × 10−21+Same SNP
Hemoglobinrs31845044.3 × 10−19+Same SNP
Celiac diseasers31845045.4 × 10−21+Same SNP
Blood eosinophil countrs31845046.5 × 10−19+Same SNP
Generalized vitiligors31845042.5 × 10−17+0.97
Soluble ICAM-1rs31845042.9 × 10−17+Same SNP
Hematocritrs31845047.9 × 10−16+Same SNP
Hypothyroidismrs31845042.6 × 10−12+Same SNP
Rheumatoid arthritis and celiac diseasers31845041.4 × 10−11+Same SNP
Primary sclerosing cholangitisrs31845045.9 × 10−11+Same SNP
Serum uraters31845042.6 × 10−10+Same SNP
Juvenile idiopathic arthritisrs31845042.6 × 10−9+0.9
Lymphocyte countrs31845041.1 × 10−8+Same SNP
Plasma beta-2 microglobulin levelsrs31845043.1 × 10−8+Same SNP
White blood cell countrs31845046.3 × 10−6+Same SNP
Rheumatoid arthritisrs31845046 × 10−6+Same SNP
Tetralogy of Fallotrs110659874.6 × 10−8+0.91
13q34COL4A1-COL4A2Coronary artery calcificationrs38093468.6 × 10−7+0.97
15q22SMAD3Crohn's diseasers172936322.7 × 10−190.9
Inflammatory bowel diseasers172936326 × 10−160.9
Ulcerative colitisrs172936329.5 × 10−60.9
Self-reported allergyrs172280581.2 × 10−80.9
15q25ADAMTS7Coronary artery calcificationrs38258076.5 × 10−6+Same SNP
17p13SMG6Aortic root sizers108529322.3 × 10−11+0.96
17q21UBE2ZHeightrs3180951.5 × 10−161
Breast size (bra cup size in women)rs126039693 × 10−51
18q21PMAIP1-MC4RObesityrs177823134.8 × 10−15+0.86
Heightrs111522136.9 × 10−13+0.91
Antipsychotic drug induced weight gainrs129678783.6 × 10−7+0.9
19q13APOE-APOC1Common carotid artery intima-media thicknessrs4459251.7 × 10−8+Same SNP
Lp-PLA2 activityrs4459253.3 × 10−10+Same SNP
Metabolic syndrome domains (Atherogenic dyslipidemia–PC1)rs4459251.3 × 10−35+Same SNP
Alzheimer diseasers20756501 × 10−295+Same SNP
Longevityrs20756503.4 × 10−17Same SNP
Lp-PLA2 activityrs20756508.1 × 10−15+Same SNP
Age-related macular degenerationrs20756508.4 × 10−8Same SNP
C-reactive proteinrs20756504.2 × 10−8+Same SNP
Cognitive decliners20756502 × 10−8+Same SNP

+ indicates increase in disease or trait with the CAD risk allele.

CAD = coronary artery disease; FEV1 = forced expiratory volume 1; FVC = forced vital capacity; ICAM-1 = intercellular adhesion molecule 1; Lp-PLA2 = lipoprotein-associated phospholipase A2; PC = principal component; SNP = single nucleotide polymorphism.