Table 2

Significant Associations of CAD Variants With Selected CV Risk Factors

LocusLocus NameLead VariantTraitEffectp Value
New Loci
6p21C2rs3130683T2D1.122.7 × 10−5
SCARB1rs11057830LDL0.0062.6 × 10−5
TG0.0228.3 × 10−5
16q13CETPrs1800775LDL0.0418.5 × 10−24
HDL−0.2023.3 × 10−644
TG0.041.3 × 10−26
Known Loci
1p32PCSK9rs11206510LDL0.0832.4 × 10−53
1p13SORT1rs602633LDL0.1591.5 × 10−261
HDL−0.0333.5 × 10−14
2p24APOBrs515135LDL0.1391.1 × 10−178
2p21ABCG5-ABCG8rs6544713LDL0.0814.84 × 10−83
4q32GUCY1A3rs7692387DBP0.3263.4 × 10−5
5q31SLC22A4-SLC22A5rs273909LDL0.0222.3 × 10−5
2q33WDR12rs6725887LDL−0.0261.3 × 10−5
6q25LPArs3798220LDL0.1586.1 × 10−11
rs2048327LDL0.0191.3 × 10−6
7q32ZC3HC1rs11556924DBPNA1.8 × 10−5
HDL−0.0181.3 × 10−5
7q36NOS3rs3918226SBP0.961.1 × 10−6
DBP0.812.2 × 10−9
8p21LPLrs264HDL−0.0988 × 10−77
TG0.0932.4 × 10−84
8q24TRIB1rs2954029LDL0.0562.1 × 10−50
HDL−0.042.7 × 10−29
TG0.0761 × 10−107
9q34ABOrs579459LDL0.0672.4 × 10−44
10q24CYP17A1-CNNM2-NT5C2rs12413409SBP1.0342 × 10−9
DBP0.4833.4 × 10−5
PP0.565.7 × 10−8
BMI−0.032.2 × 10−8
11q23ZNF259-APOA5-APOA1rs964184LDL0.0862 × 10−26
HDL−0.1076.1 × 10−48
TG0.2346.6 × 10−244
12q24SH2B3rs3184504LDL−0.0274.2 × 10−12
HDL−0.0264.1 × 10−12
SBP0.5982 × 10−9
DBP0.4838.8 × 10−6
BMI−0.1319.4 × 10−6
15q26FURIN-FESrs17514846SBP0.5091.2 × 10−5
17p13SMG6rs2281727BMI0.0153.64 × 10−6
18q21PMAIP1-MC4Rrs663129HDL−0.0265.5 × 10−9
BMI0.0568.8 × 10−53
19p13LDLRrs1122608LDL0.0748.5 × 10−57
19q13APOE-APOC1rs2075650LDL0.1771.7 × 10−214
HDL−0.0559.7 × 10−26
TG0.0442.3 × 10−21
BMI−0.0261.3 × 10−8
rs445925LDL0.3636.6 × 10−397
HDL−0.0511.9 × 10−10
TG0.1013.6 × 10−39

BMI = body mass index; CAD = coronary artery disease; CV = cardiovascular; DBP = diastolic blood pressure; HDL = high-density lipoprotein; LDL = low-density lipoprotein cholesterol level; T2D = type 2 diabetes mellitus; TG = triglycerides.

  • Effects are either absolute beta estimates of the association of the CAD risk allele on the trait (with a positive association indicating a higher value of the trait per copy of the risk allele) or log odds ratio for diabetes mellitus, †per copy of the risk allele. This table only includes associations that passed Bonferroni correction.