Table 1

Novel Loci Significantly Associated With CAD

Lead VariantLocusLocus NameA1/2 (Freq)DiscoveryReplicationMeta-AnalysisKnown Associations With Lead Variant
Cases/Control SubjectsOR (95% CI)p ValueCases/Control SubjectsOR (95% CI)p ValueOR (CI 95%)p Value
rs18012512q37KCNJ13-GIGYF2A/G (0.35)42,332/78,2291.06 (1.04–1.08)1.46 × 10−830,528/42,5211.03 (1.01–1.06)0.0071.05 (1.03–1.06)1.48 × 10−9
rs31306836p21C2T/C (0.86)39,494/72,2671.09 (1.06–1.13)7.87 × 10−830,450/42,4851.09 (1.05–1.14)2.97 × 1051.09 (1.07–1.12)1.04 × 10−11
rs1104293711p15MRVI1-CTR9T/G (0.49)42,335/78,2341.05 (1.03–1.07)3.21 × 10−830,533/42,5271.03 (1.00–1.05)0.0191.04 (1.03–1.06)1.18 × 10−8Bipolar disorder and schizophrenia
rs1117211312q13LRP1C/T (0.41)42,335/78,2341.06 (1.04–1.08)1.78 × 10−828,503/36,4331.06 (1.03–1.08)1.16 × 10−61.06 (1.04–1.07)9.25 × 10−14Migraine, pulmonary function
rs1105783012q24SCARB1A/G (0.15)42,331/78,2371.09 (1.06–1.11)3.69 × 10−1020,395/30,5921.07 (1.03–1.11)0.00031.08 (1.06–1.10)4.61 × 10−13Vitamin E level
rs180077516q13CETPC/A (0.51)38,810/62,7561.06 (1.04–1.08)2.21 × 10−822,445/32,1481.03 (1.00–1.05)0.0321.04 (1.03–1.06)9.83 × 10−9HDL cholesterol

A1/2 = allele 1/allele 2; CAD = coronary artery disease; CI = confidence interval; freq = frequency of allele 1; HDL = high-density lipoprotein; OR = odds ratio for disease for carriers of allele 1.