Author + information
- Received January 14, 2009
- Revision received March 10, 2009
- Accepted March 23, 2009
- Published online July 14, 2009.
- Thananya Boonyasirinant, MD⁎,§,
- Prabhakar Rajiah, MD⁎,
- Randolph M. Setser, DSc⁎,
- Michael L. Lieber, MS†,
- Harry M. Lever, MD‡,
- Milind Y. Desai, MD⁎,‡ and
- Scott D. Flamm, MD⁎,‡,⁎ ()
- ↵⁎Reprint requests and correspondence:
Dr. Scott D. Flamm, Cardiovascular Imaging Laboratory, J1-4, Imaging Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195
Objectives The aim of the study was to determine if patients with hypertrophic cardiomyopathy (HCM), both with and without myocardial fibrosis, have altered aortic stiffness as assessed by magnetic resonance imaging (MRI) pulse wave velocity (PWV) measurements.
Background Abnormal aortic stiffness implies an unfavorable prognosis and has been established in a variety of aortic diseases and ischemic cardiomyopathy. However, the relationship between aortic stiffness and HCM has not been studied previously.
Methods The study was institutional review board approved and Health Insurance Portability and Accountability Act of 1996 compliant. Velocity-encoded MRI was performed in 100 HCM and 35 normal control subjects. PWV was determined between the mid-ascending and -descending thoracic aorta. Delayed-enhancement MRI was acquired for identification of myocardial fibrosis.
Results Mean age was 52.4 years in HCM and 45.3 years in control subjects. The prevalence of myocardial fibrosis in HCM was 70%. PWV was significantly higher in HCM patients compared with control subjects (8.72 ± 5.83 m/s vs. 3.74 ± 0.86 m/s, p < 0.0001). PWV was higher (i.e., increased aortic stiffness) in HCM patients with myocardial fibrosis than in those without (9.66 ± 6.43 m/s vs. 6.51 ± 3.25 m/s, p = 0.005).
Conclusions Increased aortic stiffness, as indicated by increased PWV, is evident in HCM patients, and is more pronounced in those with myocardial fibrosis. Further, aortic stiffening may adversely affect left ventricular performance. In addition, increased aortic stiffness correlates with myocardial fibrosis, and may represent another potentially important parameter for risk stratification in HCM, warranting further study.
- aortic stiffness
- pulse wave velocity
- hypertrophic cardiomyopathy
- myocardial fibrosis
- magnetic resonance imaging
- Received January 14, 2009.
- Revision received March 10, 2009.
- Accepted March 23, 2009.
- American College of Cardiology Foundation