Author + information
- Sujethra Vasu,
- James F. Lovato,
- J. Greg Terry,
- Herman A. Taylor,
- Ervin Fox,
- Adolfo Correa,
- Joseph Yeboah,
- W. Gregory Hundley and
- J. Jeffrey Carr
Aortic stiffness and hypertension increase with age. Hypertension (HTN) is highly prevalent in African Americans (AA). Risk factors associated with aortic stiffness (effective aortic elastance, EAI) have not been studied in AA. We hypothesized that age and hypertension would be associated with increased EAI in AA.
We studied 1036 AA men and women from the community based Jackson Heart Study (Jackson, MS) who underwent a cardiac MRI. Subjects with an EF <50% were excluded. Left ventricular volumes were calculated using cine MRI and systolic BP was recorded. We assessed EAI as: EAI= End-systolic pressure (ESP)/ Stroke volume indexed to body-surface area, where ESP = 0.85*Systolic BP. The association between age, gender, HTN, diabetes and obesity with EAI was assessed by linear regression.
Of the 1036 subjects, 64% were hypertensive, 12% diabetic, 53% obese, 35% overweight, and 66% were female. Age was associated with an increase in EAI (β=0.029, se=0.003, p < 0.0001), without any interaction with obesity or diabetes. HTN and diabetes were not associated with EAI after adjusting for age and gender. Obesity by BMI category was significantly associated with EAI after adjusting for age, gender, HTN and diabetes (mean EAI for normal=3.06, for overweight=3.35, for obese=3.61, p < 0.0001).
In African Americans, obesity, not hypertension or diabetes, increases aortic stiffness. The relationship between aortic stiffness and ventricular remodeling deserves further study.
Poster Sessions, Expo North
Monday, March 11, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Imaging: MRI VI – Clinical Applications and Advances in CMR
Abstract Category: 19. Imaging: MRI
Presentation Number: 1310-315
- 2013 American College of Cardiology Foundation