Author + information
- Elliott Elias,
- Eduardo Pozo,
- Vijayapraveena Paruchuri,
- Juan Gaztanaga,
- Jagat Narula,
- Sean Pinney,
- Valentin Fuster and
- Javier Sanz
T1 mapping with cardiac magnetic resonance (CMR) is already validated for the quantification of interstitial fibrosis. We aimed at further exploring associations between myocardial post-contrast T1 reductions as a surrogate for interstitial fibrosis with left ventricular (LV) structure and function in non-ischemic dilated cardiomyopathy (NIDCM).
Patients with NIDCM and LV ejection fraction (LVEF) <40% referred for CMR evaluation were retrospectively identified. T1 times were obtained after the administration of gadolinium from the interventricular septum by a validated Look-Locker sequence. LV end-systolic and end-diastolic volumes, LV mass, LVEF, and presence of late gadolinium enhancement (LGE) were calculated from standard images.
We included 113 patients (75 males [67%], age 58 ± 16 years, mean LVEF: 26.5 ± 8.1%). Reduced T1 times were associated with decreases in LVEF and increases in LV end systolic volumes, LV end diastolic volumes, and LV mass (Table). When the analysis was restricted to patients without LGE (n=18), these correlations remained significant (Table).
|All patients||LGE (−) patients|
|Variable||(r) coefficient||p-value||(r) coefficient||p-value|
|LV Mass (g)||−0.27||0.005||−0.49||0.047|
LVEF – left ventricular ejection fraction; LVESV – left ventricular end systolic volume; LVEDV – left ventricular end diastolic volume; LV mass – left ventricular mass; LGE – late gadolinium enhancement; ns = not significant
Reduction in post-contrast myocardial T1, a surrogate of diffuse interstitial fibrosis, is associated with LV systolic dysfunction, dilatation and hypertrophy in NIDCM.
Poster Sessions, Expo North
Monday, March 11, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Imaging: MRI VI – Clinical Applications and Advances in CMR
Abstract Category: 19. Imaging: MRI
Presentation Number: 1310-317
- 2013 American College of Cardiology Foundation