Author + information
- Dirk van Osch,
- Juerg Schwitter,
- Emanuel Kanal,
- Matthias Schmitt,
- Frederic Anselme,
- Timothy Albert,
- David Hayes,
- David Bello,
- Attila Toth,
- Yanping Chang and
- Torsten Sommer
The Advisa MRI™ SureScan® Pacing System is an MR conditional pacing system designed to safely undergo magnetic resonance image (MRI) scans. Its influence on image quality, particularly of cardiac MR (CMR) acquisitions, is not well known. The Advisa MRI Study evaluated the CMR image quality and characterized the myocardial contraction patterns.
In this international trial with 35 participating centers, 269 patients were enrolled and an Advisa MRI System was implanted in 263 patients. Of those, 177 were randomized to the MRI group and 150 underwent MRI scans at the 9-12 week visit. Left ventricular (LV) and right ventricular (RV) cine long-axis steady-state free precession (SSFP) MR images were graded for quality. Signal loss along the implantable pulse generator and leads was also measured. The tagging CMR data quality was assessed as the percentage of trackable tagging points on CSPAMM (complementary spatial modulation of magnetization) acquisitions (n=16) and segmental circumferential fiber shortening was quantified.
Of all cine long-axis SSFP acquisitions, 95% of the LV and 98% of the RV acquisitions were of diagnostic quality, with 84% and 93% respectively being of good or excellent quality. Tagging points were trackable from systole into early diastole (360-648 ms after the R wave) in all segments. During RV pacing, tagging demonstrated a dyssynchronous contraction pattern, which was not observed in non-paced (n=4) and right atrial-paced (n=8) patients.
In the Advisa MRI Study, high quality CMR images for the assessment of cardiac anatomy and function were obtained in patients with an implantable pacing system. In addition, this study demonstrated the feasibility of acquiring tagging data to study the LV function during pacing.
Poster Sessions, Expo North
Monday, March 11, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Imaging: MRI VI – Clinical Applications and Advances in CMR
Abstract Category: 19. Imaging: MRI
Presentation Number: 1310-319
- 2013 American College of Cardiology Foundation