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Patients with psoriasis arthritis (PsA) have an increased risk of developing early myocardial impairment. This aim of study was to evaluate left ventricular (LV) mechanics in multidimensional planes and rotation in PsA patients and detect disease-related risk factors.
Seventy-six patients with PsA (33 without cardiovascular risk factors) and 24 healthy control subjects underwent conventional and 2-dimensional speckle tracking echocardiography. All participants received conventional echocardiography with speckle tracking imaging. Global longitudinal (ɛ-long), apical circumferential (ɛ-circum) and radial strain (ɛ-radial), apical rotation and maximal untwisting rate (URmax) during early diastole were measured.
Although patients with PsA had normal LV ejection fraction (>50%), the myocardial deformation in multidimensional planes has been impaired compared with control subjects (ɛ-long: 19.6±2.9 vs. 21.7±2.5, ɛ-circum: 22.1±5.2 vs. 33.6±4.8, rotation: 10.3±4.3 vs. 19.4±4.9, URmax: 64.7±28.8 vs. 103.7±44.0, p<0.005). Based on the cut-off point derived from the apical rotation of control subjects (<9.6 degree), there were 81% patients with subclinical systolic and/or diastolic dysfunction and similar prevalence was found in patients without CV risk factors. Spearman correlation demonstrated a relationship between DAS28 (disease activity score) (r=0.299, p=0.011), ESR (r=0.309, p=0.008) and impaired apical rotation even after adjusting for age and hypertension. No correlation was found between ɛ-long, ɛ-radial, ɛ-long and disease activity.
Early impaired myocardial deformation was common in patients with PsA even without CV risk factors. Apical rotation was associated with the status of PsA disease activity, which can be detected by the speckle tracking echocardiography.
Poster Sessions, Expo North
Monday, March 11, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Imaging: Cardiac Abnormalities in Non-Cardiac Disorders, Hand Held Echocardiography, Cardiac Masses
Abstract Category: 18. Imaging: Echo
Presentation Number: 1311-325
- 2013 American College of Cardiology Foundation