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Our aim is to study the systolic function of sickle cell disease pediatric patients measuring strain and strain rate. Repeated measures are done over 1-2 year time period.
We recruited 34 patients (mean age10.6±6 yrs) with repeated studies and normal ejection fraction. Echocardiography images were collected for offline analysis using Velocity Vector Imaging to measure global left ventricle (LV) longitudinal peak strain(S) and peak strain rate (SR) and right ventricle (RV) longitudinal S and SR. Also circumferential global LV S and SR at the level of the mitral valve were measured. We compared results with 35 matched normal controls (mean13.3±3.5 yrs). One-Way ANOVA was used to compare between groups.
There was significant decline of longitudinal systolic S and SR of LV for patients in both studies compared to normal controls(Table). For RV, only SR showed mild depression in patients while S was not changed. Circumferential S and SR showed no significant difference compared to normal controls. There was statistical difference between the first and second studies for patients for LV circumferential S and SR (p value≤ 0.05) but without clinical significance.
Our study reports for the first time silent LV systolic myocardial depression detected by a robust strain technique. Ejection fraction preservation could be due to sparing circumferential myocardial fibers. RV deterioration may be slower. Longer follow up is needed to detect significant changes.
|Controls||1st echo||2nd echo||p value|
Poster Sessions, Expo North
Monday, March 11, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Imaging: Echo XV
Abstract Category: 18. Imaging: Echo
Presentation Number: 1313-343
- 2013 American College of Cardiology Foundation