Author + information
- Tami L. Bair,
- Heidi May,
- Brigham Smith,
- Shadi Karabsheh,
- Qunyu P. Li,
- Anwar Tandar,
- Jeffrey Anderson,
- Donald Lappe and
- J. Muhlestein
Vitamin (Vit) D is a critical factor related to calcium (CA) absorption and metabolism, and Vit D levels are associated with serum CA levels, coronary artery disease (CAD) and major adverse CV events. Additionally, severity of coronary calcification has been used as a surrogate marker for CAD severity. However, whether either Vit D or serum CA levels are associated with severity of coronary calcification is unknown.
A total of 1,728 consecutive pts (age=63±12 yrs; males=61%, severe [≥70% stenosis in at least one major vessel] CAD=61%) undergoing clinically indicated coronary arteriography with available baseline demographics, Vit D and CA levels were included in the study. To assess fluoroscopic severity of coronary calcification, we developed a novel scoring system, reporting both extent (0-3) and severity (0-3) for each major coronary vessel. A global score for each individual pt was determined by multiplying extent and severity score for each vessel scored and adding all the scored vessels (range=0-36; categorized into 4 levels of severity: 0 [n=1225], 1-2 [n=163], 3-4 [n=118], ≥5 [n=222]). Vit D levels (ng/dL) were stratified into normal (>30; n=273), low (16-30; n=1266), and very low (≤15; n=189) categories. Associations between Vit D and coronary calcium severity categories were then made and correlations between serum CA levels and coronary calcium severity were determined.
No significant association between Vit D categories and mean coronary calcium scores (normal=1.41±3.4; low=1.93±4.3; very low=1.58±3.8; p=0.13) was found, as also between coronary calcium severity categories and mean Vit D levels (ng/dL) (0 = 24.4±9.0; 1-2 = 23.9±6.2; 3-4 = 24.5±10.1; >5 = 24.5±8.1; p=0.89). Additionally, no significant correlations were found between serum CA levels and global coronary severity score (r=0.004, p=0.88) or calcium global score categories (r=0.02, p=0.44).
Despite the known relationship between Vit D and CA metabolism, no association between either serum levels or severity of coronary calcification could be found. The underlying mechanism of differential calcification of coronary atherosclerotic plaque remains to be discovered.
Moderated Poster Contributions
Poster Sessions, Expo North
Saturday, March 09, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Chronic CAD: Inflammation, Thrombosis and Calcification
Abstract Category: 9. Chronic CAD/Stable Ischemic Heart Disease: Basic
Presentation Number: 1153M-60
- 2013 American College of Cardiology Foundation