Author + information
- Mark J. Schuuring,
- Annelieke van Riel,
- Jeroen Vis,
- Marielle Duffels,
- Rolf Berger,
- Elke Hoendermis,
- Arie Van Dijk,
- Hubert Vliegen,
- Barbara Mulder and
- Berto Bouma
Pulmonary arterial hypertension due to congenital heart disease (CHD-PAH) remains a devastating disease. We aimed to determine early electrocardiographic (ECG) markers of mortality in this subset of patients.
In this multicenter study we prospectively evaluated 75 consecutive adults (age 46 ± 13 years, 43% male) with CHD-PAH referred for advanced medical therapy. Heart rate (HR), PR interval, QRS duration and QT dispersion were derived from ECGs, which were performed routinely.
During a median follow up of 5.6 (range 0.2 to 7.5) years 19 patients died. Before treatment initiation (HR per 10-beats/min increase 1.58, 95% CI 1.15 to 2.17) a higher HR at rest was a determinant of mortality (p <0.01), see Table. Patients with a HR above 85 beats/min had a three times higher risk of mortality as compared to patients with a HR below 85 beats/min at rest (p = 0.03)
ECG-derived heart rate at rest is an important marker of prognosis and could be involved in clinical decision making.
|Hazard ratio||95% CI||p|
|ECG at baseline|
|Heart rate (per 10-beats/min increase)||1.58||1.15 – 2.17||< 0.01|
|PR interval (per 10 ms)||1.00||0.99 – 1.01||0.92|
|QRS duration (per 10 ms)||0.91||0.76 – 1.09||0.29|
|QT dispersion (per 10-ms increase)||1.07||0.91 – 1.25||0.43|
Poster Sessions, Expo North
Sunday, March 10, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Pulmonary Hypertension: Right Ventricle / Congenital Heart Disease
Abstract Category: 27. Pulmonary Hypertension
Presentation Number: 1208-156
- 2013 American College of Cardiology Foundation