Author + information
- Malik Al-Omari,
- Charles D. Burger,
- Khadija Alassas,
- Gary Lane,
- Joseph Blackshear,
- Steven Ung,
- Robert Safford,
- Christopher Austin,
- Preetham Kumar,
- Pragnesh Parikh and
- Brian Shapiro
Little is known about the prevalence of left ventricular diastolic function (LVDF) and its prognostic value in patients with group 1 pulmonary arterial hypertension (PAH).
All patients seen in the Pulmonary Hypertension Clinic, Mayo Clinic Florida from Jan 1, 1991 to Jan 16, 2012 who had 2D-echo and right heart cath (RHC) within 1 month of each other were reviewed. Peak mitral early (E) and late (A) diastolic filling velocity, pulmonary venous flows, and chambers quantification were done based on ASE guideline. LVDF was graded based on mitral and pulmonary venous flow. Mean RA pressure (mRAP), mean PA pressure (mPAP), Cardiac index (CI) obtained from RHC data. Survivorship was determined using medical record and SSDI. Statistical analyses were done using JMP with significance when p-value< 0.05.
86 patients met inclusion criteria. The mean age was 63±13 years, 71% women, 87% Caucasian, with a mean follow-up of 3.4±1.1 year. Normal LVDF, impaired relaxation, pseudonormal, and restrictive filling were seen in 14.9%, 59%, 10.5%, and 7% of patients respectively. E<0.6 m/S correlated with mRAP, mPAP and CI (P<0.05). E/A ratio correlated with mRAP, mPAP (P<0.05), but not CI. E/e’ did not correlate with right-sided pressures. An E/A <0.8 was associated with worse survival (Figure).
In this series of Group 1 PAH, LV diastolic dysfunction was present in >75% of patients. Parameters of LV diastolic dysfunction were associated with worse right-sided pressures and poor survival.
Moderated Poster Contributions
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Pulmonary Hypertension: Epidemiology, Prognosis, Outcomes
Abstract Category: 27. Pulmonary Hypertension
Presentation Number: 1251M-156
- 2013 American College of Cardiology Foundation