Author + information
- Ahmad Masri,
- Lee Pierson,
- Nicholas Smedira,
- Bruce Lytle,
- Maran Thamilarasan,
- Peyman Naji,
- Harry Lever,
- Leslie Cho and
- Milind Desai
Hypertrophic cardiomyopathy (HCM) patients have functional capacity impairment, which is due to left ventricular outflow tract obstruction (LVOTO), mitral regurgitation (MR) & LV dysfunction. Cardiopulmonary stress testing (CPT), with echocardiography, are used for symptom evaluation in hypertrophic cardiomyopathy (HCM) patients. We sought to study predictors of long-term outcomes in HCM patients undergoing CPT with echocardiography.
HCM patients (n=1017, age 50±14 years, 63% males, 77 % on betablockers) that underwent CPT with echocardiography were studied. Clinical and echocardiographic [LV thickness, resting & post-exercise LVOT gradient (mm Hg), diastolic function & MR] & exercise variables [peak VO2 (ml/kg/min), metabolic equivalents & heart rate recovery (HRR) at 1st minute post-exercise] data were recorded. Endpoint was composite: death, appropriate internal defibrillator (ICD) discharge & witnessed revival from sudden death.
Mean LV ejection fraction, maximal LV thickness, resting & post-exercise LVOT gradients were 62±6%, 2.1±0.5 cm, 41±39 & 92±51, respectively. Peak VO2, HRR and METs were 21±6, 70 ± 21, 28±14 & 6.6±1.9 respectively. Over 6±3 years of follow-up, there were 64 (6%) events; 574 (56%) patients underwent myectomy. Cox Proportional survival analysis is shown in Figure.
Age, PVO2, HRR, maximal LV thickness & surgery to relieve LVOTO are predictors of long-term outcomes in HCM patients undergoing CPT with echocardiography.
Moderated Poster Contributions
Poster Sessions, Expo North
Monday, March 11, 2013, 9:45 a.m.-10:30 a.m.
Session Title: What to Look for When Evaluating Hypertrophic Cardiomyopathy
Abstract Category: 23. Pericardial/Myocardial Disease
Presentation Number: 1295M-152
- 2013 American College of Cardiology Foundation