Author + information
- Tushar A. Tuliani,
- Luis Afonso,
- Abhishek Deshmukh,
- Maithili Shenoy,
- Kaustubh Dabhadkar,
- Sadip Pant and
- Diane Levine
Studies suggest sub clinical hypothyroidism (SCH) is related to cardiovascular mortality (CVM). We explored the relationship of SCH on the prevalence of microalbuminuria (MIA) which is a strong marker for CV disease.
We explored the NHANES-III database (n=6812). We excluded individuals <40 years, TSH levels ≥20 and ≤0.35mIU/L, eGFR<60 ml/min/1.73m2and urine albumin to creatinine ratio (UCR) of >250 mg/g in men and >355 mg/g in women (macroalbuminuria). We defined SCH as individuals with TSH levels between 5-19.99 mIU/L and serum T4 levels between 5-12 µg/dl. Individuals with TSH levels between 0.36-4.99 were considered euthyroid. MIA was defined as UCR of 17-250 mg/g in men and 25-355 mg/g in women. Survey weights were used to account for complex survey design.
Prevalence of African American ethnicity was 9.5% versus 3.2% (p-value-<0.001), male sex 48.9% versus 28.7% (p-value-<0.001), mean age 55.3 versus 59.6 years (p-value-<0.001), MIA 11.9% versus 19.2% (p-value-0.001), diabetes 8.1% versus 9.3% (p-value-0.6), hypertension 34.4% versus 43.3% (p-value-0.02) in individuals with euthyroid (n=6503) and SCH group (n=309) respectively. The odds of having microalbuminuria was 1.75 (95% CI-1.24-2.48, p-Value-0.002) and 1.83 (95% CI −1.2-2.79, p-Value-0.006) on univariate and step-wise multivariate logistic regression models respectively, in individuals with SCH.
SCH is a strong independent predictor of MIA in a healthy population.
Moderated Poster Contributions
Poster Sessions, Expo North
Saturday, March 09, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Prevention: Cardiovascular Risk Factors
Abstract Category: 24. Prevention: Clinical
Presentation Number: 1146M-9
- 2013 American College of Cardiology Foundation