Author + information
- Otto Alexander Sanchez,
- Daniel Duprez,
- Hossein Bahrami,
- Lori Daniels,
- Aaron Folsom,
- Joao Lima,
- Alan Maisel,
- Carmen Peralta and
- David Jacobs
Although high NT-proBNP (BNP) is well known as a predictor of future hypertension, the finding that brain natriuretic peptide increases lipolysis and mitochondrial function suggests that it may also be involved in the metabolism of blood lipids. It was recently reported that the association between BNP and blood pressure categories followed a biphasic pattern. This finding led us to hypothesize that the associations of BNP with LDL-C and triglycerides are inverse, following a biphasic response.
5335 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) population, 45-84 years of age, free of overt cardiovascular disease at baseline in 2000-02, had fasting venous blood sampling and other measures. Linear regressions of BNP with LDL-C and triglycerides were performed and adjusted for age, race, sex, BMI, % of total calories from saturated fats, daily physical activity, statin use, presence of diabetes, and glomerular filtration rate. Differences in the slope of these associations were determined at BNP levels < and ≥ 100 pg/mL using a linear spline.
LDL-C and triglycerides have an inverse association with BNP < 100 pg/mL, but plateau at BNP levels ≥ 100 pg/mL (differences in slopes, p < 0.0001, Figure).
These results are consistent with an inverse relation of BNP with blood lipids in a “physiologic” range of BNP <100 pg/mL. Loss of these associations at higher BNP likely reflects myocardial remodeling and strain rather than BNP physiologic function.
Poster Sessions, Expo North
Saturday, March 09, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Prevention: Risk Factors, from Tooth Loss to Resistin
Abstract Category: 24. Prevention: Clinical
Presentation Number: 1147-16
- 2013 American College of Cardiology Foundation