Author + information
- Majd AlGhatrif,
- James Strait,
- Christopher Morrell,
- Marco Canepa,
- Jeanette Wright,
- Samer Najjar,
- Luigi Ferrucci and
- Edward Lakatta
Carotid-femoral pulse wave velocity (PWV), a marker of arterial stiffness that increases with advancing age, though related to blood pressure (BP), is an established independent cardiovascular CV risk factor. Essentially no information is available on the pattern and rate of longitudinal trajectories in PWV within an individual and how this is affected by the concurrent BP projector, or differs by sex. Such information is crucial with respect to elucidating mechanisms that underlie arterial stiffening and predominately systolic hypertension that accompanies advancing age, and to design interventions to modify arterial stiffness.
Between 1988 and 2011, we collected 2 to 9 serial measures on PWV and BP in 318 men and 373 women of the Baltimore Longitudinal Study on Aging who were 21 to 94 years of age and free of clinically significant CV disease.
Linear mixed-effect models demonstrate age-blood pressure-gender differences in the longitudinal PWV trajectories: a non-linear increase in PWV rate occurs in men with aging, accelerating from 0.55 (m/s) per decade at age 40 to 1.24 (m/s) per decade at age 80. Women, exhibit a linear increase in PWV at 0.60 (m/s) per decade over the entire age spectrum studied. The sex difference in rate of increase results in gender differences in PWV after the age of 50. Interestingly, compared to rates of change in PWV of 0.3-0.5 (m/s) per decade at systolic blood pressure(SBP) <120 mm-hg, SBP between 120 and 139 mm-hg is associated with faster rate of change of 0.8-1.1 (m/s) per decade in men and 0.6-0.7 (m/s) per decade in women. A SBP ≥ 140 was associated with even a faster longitudinal increase in PWV in men, and the accelerated increase with age reached a rate of 1.8 (m/s) per decade at age of 80. Except for waist circumference in women, none of the other traditional CVD risk factors predicted longitudinal change in PWV.
The rate of PWV increase over time in men accelerates with each decade but in women this increase is linear over time, leading to gender difference that expands with advancing age. SBP, even in the pre-hypertensive range and a chronic increase in SBP, is associated with acceleration of the longitudinal PWV increase in both men and women.
North, Room 121
Sunday, March 10, 2013, 8:00 a.m.-8:15 a.m.
Session Title: Prevention: Blood Pressure – Hot Topics for 2013
Abstract Category: 25. Prevention: Hypertension
Presentation Number: 918-3
- 2013 American College of Cardiology Foundation