Author + information
- Amita Singh,
- Sean Heffron,
- Jonathan Zagzag,
- Heekoung Youn,
- George Fielding,
- Christine Ren-Fielding and
- James Underberg
Obesity is associated with a preponderance of small, atherogenic LDL, and low HDL-C levels. Favorable changes in lipid patterns have been described following bariatric surgery, but few studies if any, have investigated the impact on LDL and HDL particle number and size.
50 patients with BMI between 30 and 40 underwent laparoscopic gastric banding. Patients were followed for five years, with physical exams and blood sampling for NMR spectroscopy performed at baseline and at annual follow-up.
There was an early reduction in LDL particle number and LDL size that was non-significant at 5 years. Increases in HDL-C were significant at 1 year and 5 years (p<0.001). A significant increase in mean HDL size and trend towards increased HDL particle number was observed after five years (see figure). Changes in particle number and size for LDL and HDL did not differ according to presence of metabolic syndrome or percent BMI loss. LDL particle number and LDL-C were significantly correlated (r = 0.724, p-value <0.001) at five years of follow-up, while HDL-C and HDL particle number were not.
Our results demonstrate that despite a significant weight loss in subjects, there was no improvement in LDL-C, LDL particle number or size. However, there was a significant increase in HDL-C and HDL particle size following gastric banding, suggesting a beneficial HDL remodeling process, which persists up to five years following the procedure.
West, Room 2006
Sunday, March 10, 2013, 8:30 a.m.-8:45 a.m.
Session Title: Prevention: Novel Investigations in Lipidology
Abstract Category: 24. Prevention: Clinical
Presentation Number: 919-5
- 2013 American College of Cardiology Foundation