Author + information
- Mehmet Ergelen,
- Huseyin Uyarel,
- Seref Kul,
- Servet Altay,
- Erkan Ayhan,
- Turgay Isik,
- Tuba Kemaloglu,
- Mehmet Gul,
- Gokhan Cicek,
- Abdurrahman Tasal,
- Ercan Erdogan,
- Mehmet A. Vatankulu and
- Murat Turfan
Leukocytes total count is an independent risk marker for cardiovascular events. The ratio between neutrophils and lymphocytes counts (NLR) has been investigated as a new predictor for cardiovascular risk. We hypothesized that admission NLR would be predictive of adverse outcomes after primary angioplasty for ST-segment elevation myocardial infarction (STEMI).
2410 consecutive STEMI patients (mean age 56.2 ± 11.7 years, 2015 male, 395 female) undergoing primary angioplasty were retrospectively enrolled into the present study. The study population was divided into tertiles based on admission NLR values. A high NLR (n=803) was defined as a value in the third tertile (>6.97), and a low NLR (n=1607) was defined as a value in the lower two tertiles (≤6.97). The median follow-up time was 21 months. Clinical characteristics, in-hospital and long-term outcomes of primary angioplasty were analysed.
High NLR group had significantly higher incidence of in-hospital cardiovascular mortality and advanced heart failure than low NLR group (5 % vs 1.4%, p<0.001; 17.1% vs 9.9%, p<0.001, respectively). The median follow-up time was 21 months. Long-term cardiovascular mortality and advanced heart failure rates were significantly higher in patients with high NLR. (7% vs 4.8 %, p=0.02; 11.4 % vs 7.3%, p=0.002, respectively). By multivariate logistic regression analysis; high admission NLR (>6.97) was found a powerful independent predictor of in-hospital cardiovascular mortality (odds ratio: 2.8, 95% confidence interval: 1.37–5.74, p=0.005).
These results suggest that high admission NLR level is associated with increased in-hospital and long-term cardiovascular mortality in patients with STEMI undergoing primary angioplasty.
Poster Sessions, Expo North
Sunday, March 10, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Percutaneous Coronary Intervention for AMI: Predictors of Outcome
Abstract Category: 1. Acute Coronary Syndromes: Clinical
Presentation Number: 1216-210
- 2013 American College of Cardiology Foundation