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Magnetic resonance imaging (MRI) is highly accurate for evaluation of heart size and structure. Left ventricular hypertrophy (LVH), defined from MRI derived left ventricular mass, has not been evaluated for its reclassification properties for coronary events in a large epidemiologic study.
Multi-Ethnic study of Atherosclerosis (MESA) is a population based study (n=6,814) of White (38%), Black (28%), Chinese (22%) and Hispanic (12%) subjects, aged 45-84 years, free from clinical cardiovascular disease. We performed post-hoc analysis (N=4,921) of the limited access dataset to analyze association of LVH with all cardiovascular and hard coronary events. LVH was defined as the upper 95th percentile of left ventricular mass index (LV end-diastolic mass/body surface area (g/m2)) for males and females without hypertension (no use of antihypertensive medications, systolic blood pressure <140 mm Hg, diastolic blood pressure <90 mm Hg). Multivariate Cox proportional hazard analysis was performed to assess the independent association between LVH and study outcomes. Net reclassification index was calculated for models including traditional risk factors with and without LVH for hard coronary events.
See Table 1
Although LVH is a strong independent predictor of cardiovascular events, it does not help in the reclassification of overall and intermediate risk population for future coronary events.
Poster Sessions, Expo North
Sunday, March 10, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Improving Heart Failure Outcomes II
Abstract Category: 28. Quality of Care and Outcomes Assessment
Presentation Number: 1200-104
- 2013 American College of Cardiology Foundation