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The clinical practice of cardiology in United States is guided by recommendations from American College of Cardiology/American Heart Association. Class 1 indication is a strong recommendation suggesting that a procedure or treatment is useful and effective. This study analyzes financial support and type of evidence provided to citing articles in support of ACC/AHA class 1 recommendations.
The references for ACC/AHA Class 1 indications were reviewed. Data regarding disclosure of funding from pharmaceutical industry, type of study and study site were obtained and grouped into the following: industry funded, non industry funded, clinical trial, case report/review, US based and international.
There were 851 references for 685 class 1 indications from eleven executive summaries of ACC/AHA. Of these 739(86.8%) were available on pubmed.govwebsite and institutional library. One hundred twenty six (21.4%) had disclosures of pharmaceutical industry funding. A total of 588 (79.6%) references were defined as clinical trial and 151 (20.4%) as clinical review or case report. There were 344 (46.5%) studies of international origin.
This study suggests that only about one in every five of the references cited in support of Class 1 ACC/AHA recommendation is either funded by pharmaceutical company or is a case report or review.To our knowledge, this is the first study that has descriptively analyzed studies cited as evidence for ACC/AHA class 1 indications.
Poster Sessions, Expo North
Monday, March 11, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Critical Appraisal of Research Methods
Abstract Category: 28. Quality of Care and Outcomes Assessment
Presentation Number: 1287-94
- 2013 American College of Cardiology Foundation