Author + information
- Georg Goliasch,
- Mayank Kansal,
- Sandeep Gangireddy,
- Makoto Amaki,
- Giuseppe Caracciolo,
- Robert T. Hurst,
- Gianni Pedrizzetti,
- Vivek Reddy,
- Jagat Narula and
- Partho P. Sengupta
Left atrial (LA) remodeling increases the risk of atrial fibrillation (AF). However, few studies have compared LA deformation in physiological and pathological patterns of LA remodeling. We therefore investigated the relation between LA and LV strains (ɛ) as a determinant of indexed LA volume (LAVi) in athletes and non–athletes over a wide range of age and diastolic function.
A total of 143 subjects were studied in two groups: 91 healthy volunteers included 77 athletes, and 52 patients with diastolic dysfunction including 27 patients with AF. LAVi was correlated with diastolic function and speckle tracking derived global LAɛand LVɛ.
For patients, LAɛand LVɛ, (Fig. A and B) independently predicted LAVi (R2=0.51, P=0.04 for both). In contrast, volunteers showed higher LAɛ(40±10 vs. 23±12%, p<0.01) despite similar LAVi (P=0.21). LAɛ in volunteers correlated with LV early (r=0.36; p<0.01), late diastolic (r=0.39; p<0.01) annular velocities and end–diastolic volume (r=0.27; P=0.02). LAɛshowed diagnostic value in differentiating pathologic and physiologic LA remodeling (Fig. C; AUC, 0.84, P< 0.01).
In patients with diastolic dysfunction, an increase in LA size is accompanied with reduced LA and LV deformation. LA size in athletes, however, is associated with dynamic diastolic flux of blood volume due to enhanced LV lengthening mechanics. This relationship may be useful for distinguishing patients with pathological and physiological pattern of LA remodeling.
West, Room 3005
Sunday, March 10, 2013, 9:15 a.m.–9:30 a.m.
Session Title: Exercise and Health: New Insights
Abstract Category: 30. Sports and Exercise Cardiology: Sports Medicine
Presentation Number: 921–8
- 2013 American College of Cardiology Foundation