Author + information
- Bimmer E. Claessen,
- George Syros,
- Roxana Mehran,
- Elias Sanidas,
- Vasiliki Chantziara,
- Irine Apostolidou,
- Giora Weisz,
- Leroy Rabbani,
- Craig Hooper and
- George Dangas
Currently, little is known about the relationship between single nucleotide polymorphisms and the risk of contrast induced acute kidney injury (CI–AKI) after PCI. The presence of the MKL1–184 C>T SNP has been associated with atherosclerosis in prior studies. The CYP3A5 gene encodes an enzyme involved in drug metabolism in vivo.
A total of 1,018 patients undergoing percutaneous coronary intervention were prospectively enrolled. MKL1–C184 >T and CYP3A5–A6986>G SNPs were successfully analysed in 1004 and 963 patients, respectively. CI–AKI was defined as 1) a relative increase in serum creatinine of ≥25%, or 2) an absolute increase in serum creatinine of ≥0.5 mg/dL within 48 hours after PCI.
72% of patients enrolled were male and 34% of patients had diabetes mellitus. Mean age was 67±8 years. CI–AKI occurred in 52 patients (5.1%). Table 1shows the occurrence of CI–AKI according to SNP status. MKL1 SNP hetero– or homozygosity was associated with a reduced risk of CI–AKI while CYP3A5 SNP hetero– or homozygosity was associated with an increased risk of CI–AKI. These associations remained significant after multivariate logistic regression analysis, correcting for age, BMI, gender, hypertension and diabetes mellitus (MKL1 OR 0.54, 95%CI 0.30–0.98, p=0.04; CYP3A5 OR 1.94, 95%CI 1.08–3.50, p=0.03).
This analysis shows an independent protective effect of MKL1–C184>T SNP and an independent harmful effect of CYP3A5–A6986>G SNP regarding the incidence of CI–AKI after PCI.
West, Room 2004
Saturday, March 09, 2013, 9:15 a.m.–9:25 a.m.
Session Title: Translational Science
Abstract Category: 43. TCT@ACC–i2: Complex Patients, Diabetes, Renal Insufficiency
Presentation Number: 2902–11
- 2013 American College of Cardiology Foundation