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Renal Insufficiency (RI) is associated with poor outcome in patients with acute coronary syndrome (ACS). Several formulas to estimate glomerular filtration rate (eGFR), as a proxy of renal function, are available, although their implication on early and late mortality in patients with ACS remains unknown.
Data was extracted from the acute coronary syndromes survey in Israel between 2002–2010. Renal function was assessed using 5 eGFR formulas: CKD- EPI, MDRD, MAYO, Inulin clearance based (IB), and Cockcroft-Gault (CG). We compared the implications of 4 stages of RI using the different eGFR formulas on in- hospital and 1-year mortality.
Included were 4039 patients with ST elevation myocardial infarction (STEMI) and 4687 patients with non ST elevation ACS (NSTE-ACS). In – hospital and 1-year mortality rates are depicited in Figure(p<0.001 for all). On multivariate analysis, RI was independently associated with early and late mortality in STEMI and non STE-ACS patients using all eGFR formulas (p<0.001 for all).
RI, as assessed by different eGFR formulas, is associated with early and late mortality in patients with STEMI or NSTE-ACS. Thus, all formulas could be used for risk stratification in ACS patients.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Comorbidity and ACS: COPD, Renal Dysfunction, Diabetes
Abstract Category: 1. Acute Coronary Syndromes: Clinical
Presentation Number: 1257-189
- 2013 American College of Cardiology Foundation