Author + information
- Taishi Yonetsu,
- William Suh,
- Farhad Abtahian,
- Koji Kato,
- Rocco Vergallo,
- Haibo Jia,
- Soo–Joong Kim,
- Iris McNulty,
- Hang Lee and
- Ik–Kyung Jang
A catheter based near–infrared spectroscopy (NIRS) system was developed to detect lipid core plaque (LCP) in the coronary arteries. We sought to compare intra–coronary near–infrared spectroscopy (NIRS) and optical coherence tomography (OCT) for the detection of lipid, also to identify NIRS signals to differentiate superficial lipid, and to characterize the plaque with yellow block chemograms on NIRS.
We investigated a total of 17 patients who underwent both OCT and NIRS. NIRS–intravascular ultrasound (IVUS) combined catheter was used throughout the study. NIRS analysis included plaque lipid core burden index (LCBI), LCP length, and the presence of yellow block (YB) on the block chemogram. OCT analysis included maximum lipid arc (LA), the length of lipid (LL), lipid index, and the thinnest fibrous cap thickness (FCT).
Twenty–five plaques with >40% plaque burden were analyzed. Lipid was detected by both NIRS and OCT in 18 plaques (72%). LCP, showing LCBI>0, was observed in 20 plaques (80%) and YB was detected in 7 plaques (28%). Plaque LCBI showed modest correlations with maximum lipid arc and lipid index by OCT (r2=0.319, p=0.003 and r2=0. 404, p=0.001, respectively). Lipid length showed a significant correlation between NIRS and OCT measurements (r2=0.581, p<0.001). There was no significant difference in NIRS parameters between superficial and deep lipid. Plaques with YB compared to those without YB showed a larger LA, longer LL, and thinner FCT (185±29° vs. 105±76°, p=0.014; 8.5±3.3mm vs. 3.3±2.7mm, p=0.001; 112±42 vs. 166±61µm, p=0.033).
NIRS and OCT parameters showed modest linear correlations in the measurement of lipid. The accurate depth of lipid in the vessel wall could not be identified by NIRS parameters. Nevertheless, yellow block chemograms represented more vulnerable features on OCT. Further investigation is warranted to determine the clinical significance of NIRS parameters.
Poster Sessions, Expo North
Sunday, March 10, 2013, 9:45 a.m.–10:30 a.m.
Session Title: Intravascular Imaging: IVUS and OCT
Abstract Category: 38. TCT@ACC–i2: Intravascular Imaging and Physiology
Presentation Number: 2108–254
- 2013 American College of Cardiology Foundation