Author + information
- Jin M. Cheng,
- Rohit Oemrawsingh,
- K.M. Akkerhuis,
- Hector Garcia,
- Sanneke De Boer,
- Robert-Jan van Geuns,
- Patrick Serruys,
- Isabella Kardys and
- Eric Boersma
This study aims to investigate associations of emerging cytokine biomarkers with intravascular ultrasound (IVUS)-derived measures of coronary athersclerosis and with occurrence of cardiac events.
Between 2008 and 2011, IVUS imaging of a non-culprit coronary artery was performed in 570 patients who underwent coronary catheterization for acute coronary syndrome (ACS) (n=309) or stable angina (n=261). Interleukin-6 (IL6), chemokine C-C ligand (CCL)-2, CCL3, CCL4, CCL5, tumor necrosis factor (TNF)-α and TNF receptor-2 were measured in stored plasma samples.
Higher levels of CCL2 (p=0.002), CCL3 (p=0.042), TNF-α (p<0.001) and lower CCL5 (p=0.025 in patients with ACS) were associated with higher coronary plaque burden. Higher TNF-α was associated with presence of thin-cap fibroatheroma (TCFA) lesions (p=0.006). Lower CCL5 was associated with presence of TCFA lesions with a plaque burden ≥70% (p=0.067). Only CCL5 was independently predictive for the composite endpoints of death, ACS or revascularization (HR per SD increase in ln-RANTES 0.74, 95%CI 0.55–0.99) and for death or ACS (HR 0.64, 95%CI 0.44–0.93) at 400 days of follow-up.
Higher serum CCL2, CCL3, TNF-α and lower CCL5 levels are associated with the extent and a more advanced phenotype of coronary atherosclerosis. CCL5, also known as RANTES, is a promising biomarker that is independently, inversely associated with occurrence of cardiac events, particularly of death and ACS.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Acute Coronary Syndromes: Role of Inflammation
Abstract Category: 1. Acute Coronary Syndromes: Clinical
Presentation Number: 1258-200
- 2013 American College of Cardiology Foundation